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心脏手术后手术瘢痕处发生的皮肤T细胞淋巴瘤:一例病例研究

Cutaneous T-cell lymphoma developing in surgical scars post cardiac surgery: A case study.

作者信息

Touyz Sarah J, Ghazawi Feras M, Netchiporouk Elena, Popradi Gizelle, Michel René P, Skamene Sonia, Lambert Christine, Hijal Tarek, Litvinov Ivan V

机构信息

Department of Acute Internal Medicine, Salford Royal NHS Foundation Trust, Salford, UK.

Division of Dermatology, University of Ottawa, Ottawa, ON, Canada.

出版信息

SAGE Open Med Case Rep. 2023 Mar 21;11:2050313X231161444. doi: 10.1177/2050313X231161444. eCollection 2023.

Abstract

Cutaneous T-cell lymphomas are a class of non-Hodgkin lymphomas characterized by the infiltration of malignant T cells into the skin. Their precise pathogenesis remains incompletely understood, but persistent and specific antigen stimulation of skin-homing CD4+ memory T cells by external or internal factors, combined with an inflammatory cytokine-rich tissue microenvironment, may be critical in the development of cutaneous T-cell lymphomas. We present herein a case of primary cutaneous T-cell lymphoma arising in two surgical scars that developed 6 months post-operatively and were successfully treated with external beam radiotherapy. This case highlights the notion that primary cutaneous T-cell lymphoma can develop locally at the site of injury/foreign body within a relatively short time post trauma/surgery. This work contributes to the literature of cutaneous T-cell lymphomas arising after a trauma, surgery, or a foreign body.

摘要

皮肤T细胞淋巴瘤是一类非霍奇金淋巴瘤,其特征是恶性T细胞浸润至皮肤。其确切发病机制仍未完全明确,但外在或内在因素对归巢至皮肤的CD4+记忆T细胞的持续且特异性抗原刺激,加上富含炎性细胞因子的组织微环境,可能在皮肤T细胞淋巴瘤的发生发展中起关键作用。我们在此报告一例原发性皮肤T细胞淋巴瘤,该肿瘤发生于两个手术瘢痕处,术后6个月出现,经外照射放疗成功治愈。该病例凸显了原发性皮肤T细胞淋巴瘤可在创伤/手术后相对短的时间内在损伤/异物部位局部发生的观点。这项工作为创伤、手术或异物后发生的皮肤T细胞淋巴瘤文献做出了贡献。

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