Touyz Sarah J, Ghazawi Feras M, Netchiporouk Elena, Popradi Gizelle, Michel René P, Skamene Sonia, Lambert Christine, Hijal Tarek, Litvinov Ivan V
Department of Acute Internal Medicine, Salford Royal NHS Foundation Trust, Salford, UK.
Division of Dermatology, University of Ottawa, Ottawa, ON, Canada.
SAGE Open Med Case Rep. 2023 Mar 21;11:2050313X231161444. doi: 10.1177/2050313X231161444. eCollection 2023.
Cutaneous T-cell lymphomas are a class of non-Hodgkin lymphomas characterized by the infiltration of malignant T cells into the skin. Their precise pathogenesis remains incompletely understood, but persistent and specific antigen stimulation of skin-homing CD4+ memory T cells by external or internal factors, combined with an inflammatory cytokine-rich tissue microenvironment, may be critical in the development of cutaneous T-cell lymphomas. We present herein a case of primary cutaneous T-cell lymphoma arising in two surgical scars that developed 6 months post-operatively and were successfully treated with external beam radiotherapy. This case highlights the notion that primary cutaneous T-cell lymphoma can develop locally at the site of injury/foreign body within a relatively short time post trauma/surgery. This work contributes to the literature of cutaneous T-cell lymphomas arising after a trauma, surgery, or a foreign body.
皮肤T细胞淋巴瘤是一类非霍奇金淋巴瘤，其特征是恶性T细胞浸润至皮肤。其确切发病机制仍未完全明确，但外在或内在因素对归巢至皮肤的CD4+记忆T细胞的持续且特异性抗原刺激，加上富含炎性细胞因子的组织微环境，可能在皮肤T细胞淋巴瘤的发生发展中起关键作用。我们在此报告一例原发性皮肤T细胞淋巴瘤，该肿瘤发生于两个手术瘢痕处，术后6个月出现，经外照射放疗成功治愈。该病例凸显了原发性皮肤T细胞淋巴瘤可在创伤/手术后相对短的时间内在损伤/异物部位局部发生的观点。这项工作为创伤、手术或异物后发生的皮肤T细胞淋巴瘤文献做出了贡献。
