Regala Joana, Lourenço João, Moniz-Pereira Francisco, Bento António
Department of Psychiatry, Psychiatric Hospital Centre of Lisbon (Hospital Júlio de Matos), Lisbon, Portugal.
Department of Neurology, Central Lisbon University Hospital Centre (Hospital Santo António dos Capuchos), Lisbon, Portugal.
Case Rep Psychiatry. 2023 Mar 16;2023:7960227. doi: 10.1155/2023/7960227. eCollection 2023.
Postictal psychosis (PIP) is one of the most common types of psychosis in epileptic patients. By virtue of the paucity of research on PIP, its pathophysiology remains not completely understood. Our case report describes a clinical picture of PIP, characterized by pleomorphic features, with neither Schneider's firstrank symptoms nor negative symptoms of schizophrenia, in a longstanding epileptic female patient with a history of nonadherence to antiepileptic treatment and poorly controlled seizures. Additionally, she had previous cognitive impairment and encephalomalacia in the right parietooccipital region as a sequela of a moderate-to-severe traumatic brain injury known to precede the emergence of the epilepsy. In light of our findings, we critically reviewed the current literature on postictal psychoses providing insight into its neurobiological underpinnings.
癫痫后精神病(PIP)是癫痫患者中最常见的精神病类型之一。由于对PIP的研究较少,其病理生理学仍未完全明确。我们的病例报告描述了一名长期患有癫痫的女性患者的PIP临床表现,其特征为多形性,既无精神分裂症的施奈德一级症状,也无阴性症状。该患者有不坚持抗癫痫治疗且癫痫发作控制不佳的病史。此外,作为中度至重度创伤性脑损伤的后遗症,她之前存在认知障碍以及右侧顶枕叶脑软化,而该创伤性脑损伤发生在癫痫出现之前。根据我们的研究结果,我们对目前关于癫痫后精神病的文献进行了批判性回顾,以深入了解其神经生物学基础。