Medley Jeffrey C, Song Mi Hye
Department of Biological Sciences, Oakland University, Rochester, Michigan, United States.
MicroPubl Biol. 2023 Mar 7;2023. doi: 10.17912/micropub.biology.000791. eCollection 2023.
Protein phosphorylation plays a critical role in cell cycle progression. In , Casein Kinase II (CK2) negatively regulates centrosome assembly, and Protein Phosphatase 2A (PP2A) acts as a positive regulator of centrosome duplication, suggesting CK2 and PP2A play opposing roles in centrosome assembly. Here, we examined the genetic interaction between encoding the catalytic subunit of CK2, and encoding the PP2Aregulatory subunit SUR-6 /B55, in embryos. Our results show that partially restores normal centrosome duplication and embryonic viability to hypomorphic mutants, suggesting that genetically suppresses in centrosome assembly during embryogenesis.
蛋白质磷酸化在细胞周期进程中起着关键作用。在[具体情况未提及处]，酪蛋白激酶II（CK2）对中心体组装起负调控作用，而蛋白磷酸酶2A（PP2A）作为中心体复制的正调控因子，这表明CK2和PP2A在中心体组装中发挥相反作用。在此，我们研究了编码CK2催化亚基的[基因名称未提及]与编码PP2A调节亚基SUR-6 /B55的[基因名称未提及]在[物种名称未提及]胚胎中的遗传相互作用。我们的结果表明，[基因名称未提及]部分恢复了低表达[基因名称未提及]突变体的正常中心体复制和胚胎活力，这表明[基因名称未提及]在[物种名称未提及]胚胎发生过程中在中心体组装方面对[基因名称未提及]具有遗传抑制作用。
