Fan DingYuan, Ma Jia, Liu XiaoHua, Zhang Sheng, Sun Jin, Li Yan, Jiang Bo, Zhang Lei
Department of Joint Surgery and Sports Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China.
Beijing University of Chinese Medicine, Beijing, China.
Front Surg. 2023 Mar 10;10:1015490. doi: 10.3389/fsurg.2023.1015490. eCollection 2023.
(), a common pathogen, contributes significantly to infections in shoulder surgery. Prevention of shoulder infection is crucial to improve postoperative functional recovery and reduce costs. This study aimed to perform a systematic review and meta-analysis to assess the safety and efficacy of 5% benzoyl peroxide (BPO) application in the shoulder to decrease .
Three electronic databases were searched as follows: PubMed, Embase, and the Cochrane Library databases. Data extraction for this study was performed by two independent reviewers, and only level I and level II studies were included. The outcome data sources of individual studies were pooled. The fixed-effect model was used to determine the meta-analysis.
There were five level I studies and five level II studies. The results showed that the 5% BPO group had a lower risk of positivity [OR, 0.21 (0.15, 0.30), = 24, < 0.00001]. The pooled analysis results showed that there was no significant difference in the ability of 5% BPO and 5% BPO + clindamycin to reduce . However, the lower rate of adverse events was significantly in favour of the non-BPO group compared with the 5% BPO group.
BPO can decrease in the shoulder to prevent infection. However, the combination of BPO and clindamycin does not enhance this effect further.
II, Systematic review and meta-analysis.
（）是一种常见病原体，在肩部手术感染中起重要作用。预防肩部感染对于改善术后功能恢复和降低成本至关重要。本研究旨在进行系统评价和荟萃分析，以评估5%过氧化苯甲酰（BPO）用于肩部以降低（此处原文缺失相关内容）的安全性和有效性。
对三个电子数据库进行如下检索：PubMed、Embase和Cochrane图书馆数据库。本研究的数据提取由两名独立 reviewers 进行，仅纳入 I 级和 II 级研究。汇总各个研究的结局数据来源。采用固定效应模型进行荟萃分析。
有五项 I 级研究和五项 II 级研究。结果显示，5%BPO组（此处原文缺失相关内容）阳性风险较低[比值比，0.21（0.15，0.30），（此处原文缺失相关内容）=24，（此处原文缺失相关内容）<0.00001]。汇总分析结果显示，5%BPO与5%BPO+克林霉素降低（此处原文缺失相关内容）的能力无显著差异。然而，与5%BPO组相比，非BPO组不良事件发生率较低，差异有统计学意义。
BPO可降低肩部（此处原文缺失相关内容）以预防感染。然而，BPO与克林霉素联合使用并未进一步增强此效果。
II，系统评价和荟萃分析。
