Dos Santos Deivid Ramos, Xavier Debora Pinheiro, de Ataíde Letícia Amanda Pinheiro, Bentes Lívia Guerreiro de Barros, Lemos Rafael Silva, Giubilei Dante Bernardes, de Barros Rui Sergio Monteiro
Laboratório de Cirurgia Experimental, Universidade do Estado do Pará, Belém, PA, Brasil.
Departamento de Ortopedia e Traumatologia do Hospital Porto Dias, Belém, PA, Brasil.
Rev Bras Ortop (Sao Paulo). 2022 Oct 20;58(1):72-78. doi: 10.1055/s-0042-1756332. eCollection 2023 Feb.
To evaluate the effects of hydrolyzed collagen and collagen peptide in the treatment of superficial chondral lesions in rats. This research employed 18 . A single intraarticular infiltration of sodium iodoacetate (2 mg solution) through the patellar ligament induced joint damage in previously anesthetized animals. We divided the animals into three groups: a control group, a collagen peptide group, and a hydrolyzed collagen group. Treatment consisted of oral administration of collagen peptide or hydrolyzed collagen for 30 days. Afterwards, we euthanized the animals and studied the joint chondral changes. We evaluated the results according to the chondrocyte clusters count and a histological evaluation, as per Pritzker et al. There was no statistical significance in injury stages between the control, hydrolyzed collagen, and collagen peptide groups ( = 0.11). Regarding scores, there was a statistical significance between the groups treated with hydrolyzed collagen and collagen peptide ( < 0.05), but not in comparison with the control group. The proposed treatments of the induced chondral lesion with the oral administration of hydrolyzed collagen or collagen peptides were effective, resulting in lesion stabilization or regression, and warranting further experimental research to understand and improve the primary outcome of this study.
评估水解胶原蛋白和胶原蛋白肽对大鼠浅表软骨损伤的治疗效果。 本研究采用了18只（动物）。通过髌韧带对先前麻醉的动物进行单次关节内注射碘乙酸钠（2毫克溶液）诱导关节损伤。我们将动物分为三组：对照组、胶原蛋白肽组和水解胶原蛋白组。治疗包括口服胶原蛋白肽或水解胶原蛋白30天。之后，我们对动物实施安乐死并研究关节软骨变化。我们根据软骨细胞簇计数和组织学评估（按照普利茨克等人的方法）来评估结果。 对照组、水解胶原蛋白组和胶原蛋白肽组之间的损伤阶段无统计学意义（P = 0.11）。关于评分，水解胶原蛋白组和胶原蛋白肽组之间存在统计学意义（P < 0.05），但与对照组相比无统计学意义。 口服水解胶原蛋白或胶原蛋白肽对诱导的软骨损伤进行的拟议治疗是有效的，可导致损伤稳定或消退，值得进一步进行实验研究以了解并改善本研究的主要结果。
