Corsi Carlos Alexandre Curylofo, Luiz Alan Vinicius Assunção, Cintra Álefe Saloum, Scarpelini Katia Carmen Gabriel, Bento Rodolfo Leandro, Garcia Flávio Luis, Picado Celso Herminio Ferraz, Martins Luís Gustavo Gazoni
Banco de Tecidos Humanos, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.
Escola de Enfermagem de Ribeirão Preto, Ribeirão Preto, SP, Brasil.
Rev Bras Ortop (Sao Paulo). 2022 Oct 13;58(1):23-29. doi: 10.1055/s-0042-1756156. eCollection 2023 Feb.
The present study aims to highlight the significance of the nucleic acid test (NAT) for musculoskeletal tissue donation and to compare the sensitivity of this test on the different available platforms. The present study is a retrospective survey in a human tissue bank database and an integrative literature review encompassing the last 10 years. The PubMed portal and the SCOPUS, CINAHL, and Web of Science databases were queried for articles. We found no specific studies on the use and sensitivity of NAT in braindead tissue donors. The information presented in the present study consists of specific contents intended for the Brazilian Blood Transfusion Network (Hemorrede Transfusional Nacional, in Portuguese) and internal retrospective data from a tissue bank located at a city in the state of São Paulo, Brazil. The NAT is effective in blood samples from living patients. However, since biochemical reactions in braindead patients can be different, specific research, platforms, or both are crucial to tissue banks.
本研究旨在强调核酸检测（NAT）在肌肉骨骼组织捐赠中的重要性，并比较该检测在不同现有平台上的敏感性。 本研究是对人体组织库数据库的回顾性调查以及对过去10年的综合文献综述。通过查询PubMed门户以及SCOPUS、CINAHL和Web of Science数据库来获取文章。 我们未发现关于脑死亡组织捐赠者中NAT使用和敏感性的具体研究。本研究提供的信息包括针对巴西输血网络（葡萄牙语为Hemorrede Transfusional Nacional）的特定内容以及来自巴西圣保罗州一个城市的组织库的内部回顾性数据。 NAT对活体患者的血样有效。然而，由于脑死亡患者的生化反应可能不同，因此对于组织库而言，特定的研究、平台或两者都至关重要。
