Kierzek R, Rozek M, Markiewicz W T
Institute of Bio-organic Chemistry, Polish Academy of Sciences, Poznan.
Nucleic Acids Symp Ser. 1987(18):201-4.
The influence of 2'-O-substituents (i.e. methyl, tetrahydropyranyl, t-butyldimethylsilyl) on the chemical synthesis of oligoribonucleotides by the phosphoroamidite approach on solid support is studied and compared with 2'-deoxynucleosides. Strong dependence on the steric hindrance of 2'-substituents both for the 3'-phosphitylation and condensation steps is described.
