Some steric aspects of synthesis of oligoribonucleotides by phosphoroamidite approach on solid support.
作者信息
Kierzek R, Rozek M, Markiewicz W T
机构信息
Institute of Bio-organic Chemistry, Polish Academy of Sciences, Poznan.
出版信息
Nucleic Acids Symp Ser. 1987(18):201-4.
PMID:3697128
Abstract
The influence of 2'-O-substituents (i.e. methyl, tetrahydropyranyl, t-butyldimethylsilyl) on the chemical synthesis of oligoribonucleotides by the phosphoroamidite approach on solid support is studied and compared with 2'-deoxynucleosides. Strong dependence on the steric hindrance of 2'-substituents both for the 3'-phosphitylation and condensation steps is described.
摘要
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