Preparation and biological activity of 5,6-dihydro-5-azapyrimidine nucleosides.
作者信息
Pískala A, Cesneková B, Veselý J
机构信息
Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Praha.
出版信息
Nucleic Acids Symp Ser. 1987(18):57-60.
PMID:3697151
Abstract
The reaction of 5-azapyrimidine nucleosides Ia-IXa with zinc powder in acetic acid afforded the respective 5,6-dihydro derivatives Ib-IXb in high yields. This procedure represents a convenient and general method for preparation of the title compounds. The effects of some dihydro-5-azapyrimidine nucleosides on the growth in vitro of L1210 mouse leukemic cells were estimated.
摘要
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