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5,6-二氢-5-氮杂嘧啶核苷的制备及其生物活性

Preparation and biological activity of 5,6-dihydro-5-azapyrimidine nucleosides.

作者信息

Pískala A, Cesneková B, Veselý J

机构信息

Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Praha.

出版信息

Nucleic Acids Symp Ser. 1987(18):57-60.

PMID:3697151
Abstract

The reaction of 5-azapyrimidine nucleosides Ia-IXa with zinc powder in acetic acid afforded the respective 5,6-dihydro derivatives Ib-IXb in high yields. This procedure represents a convenient and general method for preparation of the title compounds. The effects of some dihydro-5-azapyrimidine nucleosides on the growth in vitro of L1210 mouse leukemic cells were estimated.

摘要

5-氮杂嘧啶核苷Ia-IXa与锌粉在乙酸中反应，以高产率得到相应的5,6-二氢衍生物Ib-IXb。该方法是制备标题化合物的一种简便通用的方法。评估了一些二氢-5-氮杂嘧啶核苷对L1210小鼠白血病细胞体外生长的影响。

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