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Ross 手术后的自体移植物再手术。

Autograft reoperations after the Ross procedure.

机构信息

Department of Thoracic and Cardiovascular Surgery, Saarland University Medical Center, Homburg/Saar, Germany.

出版信息

Eur J Cardiothorac Surg. 2023 May 2;63(5). doi: 10.1093/ejcts/ezad117.

Abstract

OBJECTIVES

After a Ross procedure, autograft failure can occur. At reoperation, repair of the autograft preserves the advantages of the Ross procedure. The aim of this retrospective study was to assess mid-term results after reoperation of a failed autograft.

METHODS

Between 1997 and 2022, 30 consecutive patients (83% male; age 41 ± 11 years) underwent autograft reintervention between 60 days and 24 years (median 10 years) after a Ross procedure. The initial technique varied, full-root replacement (n = 25) being the most frequent. The indication for reoperation was isolated autograft regurgitation (n = 7), root dilatation (>43 mm) with (n = 17) or without (n = 2) autograft regurgitation, mixed dysfunction (n = 2) and endocarditis (n = 2). In 4 instances, the valve was replaced by valve (n = 1) or combined valve and root replacement (n = 3). Valve-sparing procedures consisted of isolated valve repair (n = 7) or root replacement (n = 19), and tubular aortic replacement. Cusp repair was performed in all but 2. Mean follow-up was 5.4 ± 6 years (35 days to 24 years).

RESULTS

Mean cross-clamp and perfusion times were 74 ± 26 and 132 ± 64 min. There were 2 perioperative deaths (7%; both valve replacement) and 2 patients died late (32 days to 1.2 years postoperatively). Freedom from cardiac death at 10 years was 96% after valve repair and 50% after replacement. Two patients required reoperation (1.68 and 16 years) following repair. One underwent valve replacement for cusp perforation, the other, root remodelling for dilatation. Freedom from autograft reintervention at 15 years was 95%.

CONCLUSIONS

Autograft reoperations after the Ross procedure can be performed as valve-sparing operations in the majority of cases. With valve-sparing, long-term survival and freedom from reoperation are excellent.

摘要

目的

在进行罗斯手术后,可能会出现自体移植物失效的情况。在再次手术中,修复自体移植物可以保留罗斯手术的优势。本回顾性研究旨在评估自体移植物失效后的中期结果。

方法

1997 年至 2022 年,30 例连续患者(83%为男性;年龄 41±11 岁)在罗斯手术后 60 天至 24 年(中位时间 10 年)之间接受自体移植物再干预。初始技术多种多样,全根置换(n=25)最为常见。再次手术的指征为孤立性自体移植物反流(n=7)、根部扩张(>43mm)伴(n=17)或不伴(n=2)自体移植物反流、混合功能障碍(n=2)和心内膜炎(n=2)。在 4 例中,瓣膜被瓣膜(n=1)或瓣膜和根部联合置换(n=3)所替代。瓣膜保留手术包括单纯瓣膜修复(n=7)或根部置换(n=19)和管状主动脉置换。除 2 例外,所有患者均进行了瓣叶修复。平均随访时间为 5.4±6 年(35 天至 24 年)。

结果

平均体外循环和灌注时间分别为 74±26 分钟和 132±64 分钟。围手术期死亡 2 例(7%;均为瓣膜置换),2 例患者术后晚期死亡(术后 32 天至 1.2 年)。10 年时无心脏死亡的生存率为瓣膜修复后 96%,置换后 50%。修复后有 2 例患者需要再次手术(分别为 1.68 年和 16 年)。1 例因瓣叶穿孔行瓣膜置换,另 1 例行根部重塑以治疗扩张。15 年时无自体移植物再干预的生存率为 95%。

结论

罗斯手术后的自体移植物再手术可以在大多数情况下作为瓣膜保留手术进行。采用瓣膜保留手术,长期生存率和免于再次手术的效果非常好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6275/10162808/476ae3fcaa3b/ezad117f3.jpg

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