Department of Biomedical Engineering, Faculty of Health, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran.
School of Biotechnology and Biomolecular Sciences, Faculty of Science, University of New South Wales (UNSW), Sydney, NSW, Australia.
Hum Brain Mapp. 2023 Jun 1;44(8):3302-3310. doi: 10.1002/hbm.26282. Epub 2023 Mar 27.
Approximately 2%-3% of the world population suffers from obsessive-compulsive disorder (OCD). Several brain regions have been involved in the pathophysiology of OCD, but brain volumes in OCD may vary depending on specific OCD symptom dimensions. The study aims to explore how white matter structure changes in particular OCD symptom dimensions. Prior studies attempt to find the correlation between Y-BOCS scores and OCD patients. However, in this study, we separated the contamination subgroup in OCD and compared directly to healthy control to find regions that exactly related to contamination symptoms. To evaluate structural alterations, diffusion tensor imaging was acquired from 30 OCD patients and 34 demographically matched healthy controls. Data were processed using tract-based spatial statistics (TBSS) analysis. First, by comparing all OCD to healthy controls, significant fractional anisotropy (FA) decreased in the right anterior thalamic radiation, right corticospinal tract, and forceps minor observed. Then by comparing the contamination subgroup to healthy control, FA decreases in the forceps minor region. Consequently, forceps minor plays a central role in the pathophysiology of contamination behaviors. Finally, other subgroups were compared to healthy control and discovered that FA in the right corticospinal tract and right anterior thalamic radiation is reduced.
大约世界人口的 2%-3%患有强迫症（OCD）。几个大脑区域已涉及 OCD 的病理生理学，但 OCD 中的脑体积可能因特定 OCD 症状维度而异。本研究旨在探讨特定 OCD 症状维度中白质结构的变化。先前的研究试图找到 Y-BOCS 评分与 OCD 患者之间的相关性。然而，在这项研究中，我们将 OCD 中的污染亚组分开，并直接与健康对照组进行比较，以找到与污染症状确切相关的区域。为了评估结构改变，从 30 名 OCD 患者和 34 名人口统计学匹配的健康对照者中采集了扩散张量成像数据。使用基于束的空间统计学（TBSS）分析处理数据。首先，通过将所有 OCD 与健康对照组进行比较，发现右侧前丘脑辐射、右侧皮质脊髓束和小内囊的分数各向异性（FA）显著降低。然后，通过将污染亚组与健康对照组进行比较，发现小内囊区域的 FA 降低。因此，小内囊在污染行为的病理生理学中起着核心作用。最后，将其他亚组与健康对照组进行比较，发现右侧皮质脊髓束和右侧前丘脑辐射中的 FA 降低。
