与基于社区的 HIV 感染老年性少数群体中抗逆转录病毒治疗依从性相关的因素。
Factors Associated with Antiretroviral Therapy Adherence Among a Community-Based Sample of Sexual Minority Older Adults with HIV.
机构信息
Department of Psychology, University of Miami, Miami, USA.
Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, USA.
出版信息
AIDS Behav. 2023 Oct;27(10):3285-3293. doi: 10.1007/s10461-023-04048-6. Epub 2023 Mar 27.
Older sexual minorities (e.g., gay, bisexual) living with HIV are at risk for poor HIV outcomes due to their frequent experience with both psychosocial challenges and structural barriers to care. This study utilized a stochastic search variable selection (SVSS) approach to explore potential psychosocial and structural factors associated with HIV-related health outcomes among a community-based sample of older sexual minorities (N = 150) in South Florida, an U.S. HIV-epidemic epicenter. After SVSS, a forward entry regression approach suggested unstable housing, illicit substance use, current nicotine use, and depression were all associated with poorer ART adherence among older sexual minority adults living with HIV. No associations between potential correlates and biological measures of HIV disease severity were observed. Findings highlight a need to focus on multiple levels of intervention that target a combination of psychosocial and structural factors to improve HIV-care outcomes among older sexual minorities and achieve Ending the HIV Epidemic goals.
老年性少数群体（例如男同性恋、双性恋）感染 HIV 后，由于经常面临心理社会挑战和获得护理的结构性障碍，其 HIV 预后较差。本研究采用随机搜索变量选择（SVSS）方法，探索了与南佛罗里达州社区中老年性少数群体（N=150）与 HIV 相关的健康结果相关的潜在心理社会和结构性因素，该群体是美国 HIV 流行的中心。经过 SVSS 后，逐步回归方法表明，不稳定的住房、非法药物使用、当前尼古丁使用和抑郁都与 HIV 阳性的老年性少数群体成年人接受抗逆转录病毒治疗的依从性较差有关。潜在相关性与 HIV 疾病严重程度的生物学指标之间没有观察到关联。研究结果强调需要关注多个干预层面，针对心理社会和结构性因素的组合，以改善老年性少数群体的 HIV 护理结果，实现终结 HIV 流行的目标。
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