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加拿大安大略省居民中,术前医疗咨询与减少术后不良结局及医疗护理流程使用之间的关联。

Association of Preoperative Medical Consultation With Reduction in Adverse Postoperative Outcomes and Use of Processes of Care Among Residents of Ontario, Canada.

机构信息

Division of General Internal Medicine, Department of Medicine, Ottawa Hospital, University of Ottawa, Ontario, Canada.

ICES, Ottawa, Ontario, Canada.

出版信息

JAMA Intern Med. 2023 May 1;183(5):470-478. doi: 10.1001/jamainternmed.2023.0325.

DOI:10.1001/jamainternmed.2023.0325
PMID:36972037
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10043801/
Abstract

IMPORTANCE

It is uncertain whether preoperative medical consultation reduces adverse postoperative clinical outcomes.

OBJECTIVE

To investigate the association of preoperative medical consultation with reduction in adverse postoperative outcomes and use of processes of care.

DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective cohort study using linked administrative databases from an independent research institute housing routinely collected health data for Ontario's 14 million residents, including sociodemographic features, physician characteristics and services, and receipt of inpatient and outpatient care. The study sample included Ontario residents aged 40 years or older who underwent their first qualifying intermediate- to high-risk noncardiac operation. Propensity score matching was used to adjust for differences between patients who did and did not undergo preoperative medical consultation with discharge dates between April 1, 2005, and March 31, 2018. The data were analyzed from December 20, 2021, to May 15, 2022.

EXPOSURES

Receipt of preoperative medical consultation in the 4 months preceding the index surgery.

MAIN OUTCOMES AND MEASURES

The primary outcome was 30-day all-cause postoperative mortality. Secondary outcomes included 1-year mortality, inpatient myocardial infarction and stroke, in-hospital mechanical ventilation, length of stay, and 30-day health system costs.

RESULTS

Of the total 530 473 individuals (mean [SD] age, 67.1 [10.6] years; 278 903 [52.6%] female) included in the study, 186 299 (35.1%) received preoperative medical consultation. Propensity score matching resulted in 179 809 well-matched pairs (67.8% of the full cohort). The 30-day mortality rate was 0.9% (n = 1534) in the consultation group and 0.7% (n = 1299) in the control group (odds ratio [OR], 1.19; 95% CI, 1.11-1.29). The ORs for 1 year mortality (OR, 1.15; 95% CI, 1.11-1.19), inpatient stroke (OR, 1.21; 95% CI, 1.06-1.37), in-hospital mechanical ventilation (OR, 1.38; 95% CI, 1.31-1.45), and 30-day emergency department visits (OR, 1.07; 95% CI, 1.05-1.09) were higher in the consultation group; however, the rates of inpatient myocardial infarction did not differ. The lengths of stay in acute care were a mean (SD) 6.0 (9.3) days in the consultation group and 5.6 (10.0) days in the control group (difference, 0.4 [95% CI, 0.3-0.5] days), and the median (IQR) total 30-day health system cost was CAD $317 ($229-$959) (US $235 [$170-$711]) higher in the consultation group. Preoperative medical consultation was associated with increased use of preoperative echocardiography (OR, 2.64; 95% CI, 2.59-2.69) and cardiac stress tests (OR, 2.50; 95% CI, 2.43-2.56) and higher odds of receiving a new prescription for β-blockers (OR, 2.96; 95% CI, 2.82-3.12).

CONCLUSIONS AND RELEVANCE

In this cohort study, preoperative medical consultation was not associated with a reduction but rather with an increase in adverse postoperative outcomes, suggesting a need for further refinement of target populations, processes, and interventions related to preoperative medical consultation. These findings highlight the need for further research and suggest that referral for preoperative medical consultation and subsequent testing should be carefully guided by individual-level consideration of risks and benefits.

摘要

重要性

术前医疗咨询是否能降低不良术后临床结局尚不确定。

目的

研究术前医疗咨询与降低不良术后结局和使用护理流程之间的关联。

设计、设置和参与者:这是一项回顾性队列研究,使用来自独立研究机构的链接行政数据库,该机构收纳了安大略省 1400 万居民的常规健康数据,包括社会人口统计学特征、医生特征和服务以及住院和门诊护理的使用情况。研究样本包括年龄在 40 岁或以上、接受首次中高危非心脏手术的安大略省居民。采用倾向评分匹配来调整接受术前医疗咨询和未接受术前医疗咨询的患者在出院日期(2005 年 4 月 1 日至 2018 年 3 月 31 日)之间的差异。数据分析于 2021 年 12 月 20 日至 2022 年 5 月 15 日进行。

暴露情况

在指数手术前的 4 个月内接受术前医疗咨询。

主要结局和测量指标

主要结局是 30 天全因术后死亡率。次要结局包括 1 年死亡率、住院期间心肌梗死和中风、院内机械通气、住院时间和 30 天的医疗系统成本。

结果

在研究的 530473 名患者中(平均[标准差]年龄,67.1[10.6]岁;278903[52.6%]为女性),186299 名(35.1%)接受了术前医疗咨询。倾向评分匹配产生了 179809 对匹配良好的患者(全队列的 67.8%)。咨询组的 30 天死亡率为 0.9%(n=1534),对照组为 0.7%(n=1299)(比值比[OR],1.19;95%置信区间[CI],1.11-1.29)。1 年死亡率(OR,1.15;95%CI,1.11-1.19)、住院期间中风(OR,1.21;95%CI,1.06-1.37)、院内机械通气(OR,1.38;95%CI,1.31-1.45)和 30 天急诊就诊(OR,1.07;95%CI,1.05-1.09)的 OR 更高,但住院期间心肌梗死的发生率没有差异。咨询组急性护理的平均(标准差)住院时间为 6.0(9.3)天,对照组为 5.6(10.0)天(差异,0.4[95%CI,0.3-0.5]天),中位(IQR)30 天总医疗系统成本为 CAD$317(229-959)(US$235[170-711]),咨询组更高。术前医疗咨询与术前超声心动图(OR,2.64;95%CI,2.59-2.69)和心脏压力测试(OR,2.50;95%CI,2.43-2.56)的使用增加以及新处方β受体阻滞剂(OR,2.96;95%CI,2.82-3.12)的更高几率相关。

结论和相关性

在这项队列研究中,术前医疗咨询并未降低不良术后结局,反而增加了不良术后结局的发生,这表明需要进一步完善与术前医疗咨询相关的目标人群、流程和干预措施。这些发现突出了进一步研究的必要性,并表明术前医疗咨询的转介和随后的检测应根据个体风险和获益的考虑仔细指导。

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