Advanced Diagnostic and Interventional Radiology Research Center (ADIR), Tehran University of Medical Sciences, Tehran, Iran.
Second Faculty of Medicine, Charles University, Prague, Czech Republic.
J Vasc Interv Radiol. 2023 Jul;34(7):1184-1191.e2. doi: 10.1016/j.jvir.2023.03.015. Epub 2023 Mar 25.
To systematically review published studies on the pregnancy rate and outcomes after uterine artery embolization (UAE) for uterine arteriovenous malformations (UAVMs).
International medical databases were searched for all English-language studies published between 2000 and 2022 on patients with UAVMs who had undergone embolization and had a subsequent pregnancy. Data on the pregnancy rate, pregnancy complications, and physiologic status of newborns were extracted from the articles. Ten case series were included in the meta-analysis, and 18 case reports on pregnancy following UAE were reviewed.
In the case series, 44 pregnancies were reported in 189 patients. The pooled estimate of pregnancy rate was 23.3% (95% confidence interval [CI], 17.3%-29.3%). The pregnancy rate was higher in studies of women with a mean age of ≤30 years (50.6% vs 22.2%; P < .05). The pooled estimate of live birth rate was 88.6% (95% CI, 78.6%-98.7%).
All published series report preservation of fertility and successful pregnancies after embolization of UAVMs. The live birth rate in these series does not differ substantially from that of the general population.
系统回顾已发表的关于子宫动脉栓塞术（UAE）治疗子宫动静脉畸形（UAVM）后妊娠率和结局的研究。
检索了 2000 年至 2022 年间发表的所有英文文献，纳入了接受栓塞治疗并有后续妊娠的 UAVM 患者的研究。从文章中提取妊娠率、妊娠并发症和新生儿生理状况的数据。10 项病例系列研究被纳入荟萃分析，18 项关于 UAE 后妊娠的病例报告进行了综述。
在病例系列研究中，189 例患者中报告了 44 例妊娠。妊娠率的合并估计值为 23.3%（95%置信区间，17.3%-29.3%）。年龄均数≤30 岁的研究中妊娠率较高（50.6%比 22.2%；P<.05）。活产率的合并估计值为 88.6%（95%置信区间，78.6%-98.7%）。
所有已发表的系列研究均报告了保留生育能力和栓塞 UAVM 后成功妊娠。这些系列的活产率与一般人群无显著差异。
