Yen Fu-Shun, Huang Jing-Yang, Lin Shih-Yi, Liao Pei-Lun, Wei James Cheng-Chung
Dr. Yen's Clinic, No. 15, Shanying Road, Gueishan District, Taoyuan 33354, Taiwan.
Institute of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd., South District, Taichung 40201, Taiwan.
Diabetes Metab. 2023 May;49(3):101443. doi: 10.1016/j.diabet.2023.101443. Epub 2023 Mar 25.
The incidence of type 1 diabetes continues to increase. However, the strategies to prevent or reduce its occurrence are inadequate. Therefore, we attempted to investigate if mothers with autoimmune disease were more likely to have children with type 1 diabetes.
We identified 1,288,347 newborns from the Taiwan Maternal and Child Health Database between January 1, 2009, and December 31, 2016, and followed them up to December 31, 2019. We used a multivariable Cox regression model to compare the childhood-onset type 1 diabetes risk between children whose mother had or did not have an autoimmune disease.
The multivariable model demonstrated significantly higher risks of type 1 diabetes in the children with maternal autoimmune disease (aHR 1.55, 95% CI 1.16-2.08), type 1 diabetes (aHR 11.33, 95% CI 4.62-27.77), Hashimoto's thyroiditis (aHR 3.73, 95% CI 1.70-8.15), and inflammatory bowel diseases (aHR 2.00, 95% CI 1.07-3.76).
This nationwide mother and child cohort study showed a higher risk of type 1 diabetes in the children whose mothers had autoimmune disease, including Hashimoto's thyroiditis, and inflammatory bowel diseases.
1型糖尿病的发病率持续上升。然而，预防或降低其发生的策略并不充分。因此，我们试图调查患有自身免疫性疾病的母亲是否更有可能生育患有1型糖尿病的孩子。
我们从台湾妇幼健康数据库中确定了1,288,347名2009年1月1日至2016年12月31日期间出生的新生儿，并对他们进行随访至2019年12月31日。我们使用多变量Cox回归模型比较母亲患有或未患有自身免疫性疾病的儿童患儿童期1型糖尿病的风险。
多变量模型显示，母亲患有自身免疫性疾病的儿童患1型糖尿病的风险显著更高（风险比1.55，95%置信区间1.16 - 2.08）、患1型糖尿病（风险比11.33，95%置信区间4.62 - 27.77）、患桥本甲状腺炎（风险比3.73，95%置信区间1.70 - 8.15）和炎症性肠病（风险比2.00，95%置信区间1.07 - 3.76）。
这项全国性的母婴队列研究表明，母亲患有自身免疫性疾病（包括桥本甲状腺炎和炎症性肠病）的儿童患1型糖尿病的风险更高。
