Department of Immunology, University Complutense of Madrid, Spain.
Department of Inmunology and Rheumatology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Hum Immunol. 2023 May-Jul;84(5-7):313-314. doi: 10.1016/j.humimm.2023.03.004. Epub 2023 Mar 25.
Nahua population (also named Aztec or Mexica) was studied for HLA class II genes in a Mexican rural city (Santo Domingo Ocotitlan, Morelos State) belonging to the nowadays Náhuatl speaking areas in Mexico. The most frequent HLA class II alleles were typical Amerindian (HLA-DRB104:07, DQB103:01 DRB104:03 or DRB104:04) and also were some calculated extended haplotypes (HLA-DRB104:07-DQB103:02,DRB108:02-DQB104:02, or DRB110:01-DQB105:01 among others). When using HLA-DRB1 Neís genetic distances, our isolated Nahua population was found to be close to other Central America Amerindians like the ancient-established Mayans or Mixe. This may suggest that Nahuas origin was also from Central America. It contrasts to legend that assumes they came from the North, and they built the Aztec Empire after submitting Central America neighbouring ethnic groups before 1519 CE when Spaniards led by Hernán Cortés arrived to Mexico.
我们对来自墨西哥农村城市（莫雷洛斯州圣多明各奥科蒂特兰）的纳瓦特尔人（也被称为阿兹特克或墨西加人）进行了 HLA Ⅱ类基因研究，该城市属于现今纳瓦特尔语地区。最常见的 HLA Ⅱ类等位基因是典型的美洲印第安人（HLA-DRB104:07、DQB103:01、DRB104:03 或 DRB104:04），还有一些计算出的扩展单倍型（HLA-DRB104:07-DQB103:02、DRB108:02-DQB104:02 或 DRB110:01-DQB105:01 等）。当使用 HLA-DRB1 Neís 遗传距离时，我们发现这个孤立的纳瓦特尔人群与其他中美洲的美洲印第安人（如古老的玛雅人或米克斯人）非常接近。这表明纳瓦特尔人的起源可能也来自中美洲。这与传说形成鲜明对比，传说他们来自北方，在 1519 年西班牙人赫尔南·科尔特斯（Hernán Cortés）率领西班牙人抵达墨西哥之前，他们征服了中美洲的邻国，建立了阿兹特克帝国。
