IRCCS Humanitas Research Hospital, Educational and Research Unit, Rozzano, Italy.
Department of Public Health, Experimental and Forensic Medicine, Section of Hygiene, University of Pavia, Pavia, Italy.
Semin Oncol. 2023 Feb-Apr;50(1-2):49-59. doi: 10.1053/j.seminoncol.2023.03.004. Epub 2023 Mar 21.
Literature encloses numerous systematic reviews (SRs) on nonpharmacologic interventions for improving cancer-related fatigue (CRF). The effect of these interventions remains controversial, and the available SRs have not been synthesized yet. We conducted a systematic synthesis of SRs and meta-analysis to determine the effect of nonpharmacologic interventions on CRF in adults.
We systematically searched 4 databases. The effect sizes (standard mean difference) were quantitatively pooled using a random-effects model. Chi-squared (Q) and I-square statistics (I²) tested the heterogeneity.
We selected 28 SRs, including 35 eligible meta-analyses. The pooled effect size (standard mean difference, 95% CI) was -0.67 (-1.16, -0.18). The subgroup analysis by types of interventions showed a significant effect in all the investigated approaches (complementary integrative medicine, physical exercise, self-management/e-health interventions).
There is evidence that nonpharmacologic interventions are associated with CRF reduction. Future research should focus on testing these interventions on specific population clusters and trajectories.
CRD42020194258.
文献中包含了许多关于非药物干预措施改善癌症相关疲劳（CRF）的系统评价（SR）。这些干预措施的效果仍存在争议，且现有的 SR 尚未被综合。我们进行了系统的 SR 综合和荟萃分析，以确定非药物干预措施对成人 CRF 的影响。
我们系统地检索了 4 个数据库。使用随机效应模型对效应大小（标准均数差）进行定量汇总。卡方（Q）和 I 平方统计量（I²）检验了异质性。
我们选择了 28 篇 SR，包括 35 项符合条件的荟萃分析。汇总的效应大小（标准均数差，95%CI）为-0.67（-1.16，-0.18）。按干预类型的亚组分析显示，所有研究方法都具有显著效果（补充整合医学、体育锻炼、自我管理/电子健康干预）。
有证据表明非药物干预措施与 CRF 减轻相关。未来的研究应集中在针对特定人群聚类和轨迹测试这些干预措施。
PROSPERO 注册号：CRD42020194258。
