高密度脂蛋白胆固醇与致癌作用。
High-density lipoprotein cholesterol and carcinogenesis.
机构信息
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
出版信息
Trends Endocrinol Metab. 2023 May;34(5):303-313. doi: 10.1016/j.tem.2023.02.009. Epub 2023 Mar 25.
High-density lipoprotein cholesterol (HDLC) has been recognized to be associated with atherosclerosis. In the past few years many studies have found that HDLC is also related to tumor development and progression. Despite some opposing views, a large number of studies support a negative association between HDLC and tumor incidence. Measuring serum HDLC concentrations may facilitate assessment of the prognosis of cancer patients and provide a biomarker for tumors. However, there is a lack of molecular mechanism studies on the link between HDLC and tumors. In this review we discuss the impact of HDLC on the incidence and prognosis of cancer in different systems, as well as prospects for the prediction and treatment of cancer in the future.
高密度脂蛋白胆固醇（HDLC）已被认为与动脉粥样硬化有关。在过去的几年中，许多研究发现 HDLC 也与肿瘤的发生和发展有关。尽管存在一些相反的观点，但大量研究支持 HDLC 与肿瘤发生率之间存在负相关。测量血清 HDLC 浓度可以帮助评估癌症患者的预后，并为肿瘤提供生物标志物。然而，目前关于 HDLC 与肿瘤之间联系的分子机制研究还很缺乏。在这篇综述中，我们讨论了 HDLC 对不同系统中癌症发病率和预后的影响，以及对未来癌症预测和治疗的展望。
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