Nagórna-Stasiak B
Instytut Nauk Fizjologicznych AR w Lublinie.
Pol Arch Weter. 1987;24(4):445-55.
The motoricity of an isolated intestinal loop under the influence of cholesterol before and after blocking the cholinergic or adrenergic receptors was recorded in 8 rabbits in chronic experiments. The adrenergic receptors wereblocked by intravenous administration of phentolamine and propranol, whereas cholinergic ones by atropine. At the same time the total level of cholesterol in vesicular bile was determined by the method of Zlatkis in 10 rabbits, and that in the wall of the jejunum by the method of Lieberman and Burchart. It was shown that cholesterol caused decrease of pressure in the intestinal loop, which was 1.3-4.1 kPa, resulting from dilatation of the intestines, if its concentration reaches 1.3-5.2 mmol/l. After blocking the adrenergic receptors and administration of cholesterol, its dilatating effect on the intestines was not observed, but most often a pressure increase in the intestinal loop by 2.3 kPa. The total cholesterol level in vesicular bile was 33.3 mmol/l, while 55.9 mg/g of tissue in the wall of the jejunum. The above studies showed that cholesterol at certain concentrations has a dilatating effect on the intestines. The dilatating mechanism of cholesterol is connected with adrenergic receptors. The concentrations of cholesterol decreasing the motoric activity of intestines are found in the organism, e.g. in bile, blood or in the intestine wall itself.
在慢性实验中，对8只家兔的离体肠袢在阻断胆碱能或肾上腺素能受体前后受胆固醇影响的运动性进行了记录。通过静脉注射酚妥拉明和普萘洛尔阻断肾上腺素能受体，而用阿托品阻断胆碱能受体。同时，用Zlatkis法测定了10只家兔胆囊胆汁中的总胆固醇水平，并用Lieberman和Burchart法测定了空肠壁中的总胆固醇水平。结果表明，当胆固醇浓度达到1.3 - 5.2 mmol/l时，由于肠道扩张，胆固醇会导致肠袢压力降低1.3 - 4.1 kPa。阻断肾上腺素能受体并给予胆固醇后，未观察到其对肠道的扩张作用，反而多数情况下肠袢压力升高2.3 kPa。胆囊胆汁中的总胆固醇水平为33.3 mmol/l，而空肠壁中的组织含量为55.9 mg/g。上述研究表明，一定浓度的胆固醇对肠道有扩张作用。胆固醇的扩张机制与肾上腺素能受体有关。在机体中，如胆汁、血液或肠壁本身，可发现降低肠道运动活性的胆固醇浓度。
