Department of Epidemiology and Global Health, Umeå University, Umeå, Sweden.
Expanded Program On Immunization, Ministry of Health, Banjul, The Gambia.
BMC Public Health. 2023 Mar 27;23(1):568. doi: 10.1186/s12889-023-15499-w.
The Hepatitis B virus that can cause liver cancer is highly prevalent in the Gambia, with one in ten babies at risk of infection from their mothers. Timely hepatitis B birth dose administration to protect babies is very low in The Gambia. Our study assessed whether 1) a timeliness monitoring intervention resulted in hepatitis B birth dose timeliness improvements overall, and 2) the intervention impacted differentially among health facilities with different pre-intervention performances.
We used a controlled interrupted time series design including 16 intervention health facilities and 13 matched controls monitored from February 2019 to December 2020. The intervention comprised a monthly hepatitis B timeliness performance indicator sent to health workers via SMS and subsequent performance plotting on a chart. Analysis was done on the total sample and stratified by pre-intervention performance trend.
Overall, birth dose timeliness improved in the intervention compared to control health facilities. This intervention impact was, however, dependent on pre-intervention health facility performance, with large impact among poorly performing facilities, and with uncertain moderate and weak impacts among moderately and strongly performing facilities, respectively.
The implementation of a novel hepatitis B vaccination timeliness monitoring system in health facilities led to overall improvements in both immediate timeliness rate and trend, and was especially helpful in poorly performing health facilities. These findings highlight the overall effectiveness of the intervention in a low-income setting, and also its usefulness to aid facilities in greatest need of improvement.
在冈比亚,能导致肝癌的乙型肝炎病毒非常普遍,十分之一的婴儿有从母亲那里感染的风险。冈比亚及时为婴儿提供乙型肝炎疫苗的情况非常低。我们的研究评估了 1)及时性监测干预是否总体上导致了乙型肝炎疫苗接种及时性的提高,以及 2)干预是否对具有不同干预前表现的卫生机构产生不同的影响。
我们使用了一个对照的中断时间序列设计,包括 16 个干预卫生机构和 13 个匹配的对照,从 2019 年 2 月至 2020 年 12 月进行监测。干预措施包括每月通过短信向卫生工作者发送乙型肝炎及时性表现指标,随后在图表上绘制表现情况。分析是在总样本和按干预前表现趋势分层的基础上进行的。
总体而言,与对照卫生机构相比,干预组的出生剂量及时性有所提高。然而,这种干预效果取决于干预前卫生机构的表现,在表现较差的机构中效果显著,而在表现中等和较强的机构中,效果分别为不确定的中度和较弱。
在卫生机构中实施一种新型的乙型肝炎疫苗接种及时性监测系统,导致了及时性的即时率和趋势的总体提高,对表现较差的卫生机构尤其有帮助。这些发现突出了干预措施在低收入环境中的总体有效性,也突出了其对最需要改进的机构的有用性。