Kovalenko O A, Tarasova N I, Ivannikova A G, Voronkova L N, Valova T M
Biofizika. 1986 Mar-Apr;31(2):278-82.
Dependence of changes in the intracellular free iron content upon cellular proliferation has been studied on mammalian cells in vitro. It has been established that picolic acid (PA)--a natural metal chelating agent of variable valency--inhibits the proliferation of cultivated pig embryo kidney cells (SPEV). Simultaneously the free iron quantity was decreased 2-fold as compared with the norm. PA block was removed by substituting PA-containing cultivated media for the PA-free one. It was accompanied by complete recovery of the free iron quantity in the cells. The regulation of cell proliferation is likely to correlate with the intracellular free iron content.
在体外对哺乳动物细胞研究了细胞内游离铁含量变化对细胞增殖的依赖性。已证实吡啶甲酸（PA）——一种可变价态的天然金属螯合剂——可抑制培养的猪胚胎肾细胞（SPEV）的增殖。同时，与正常情况相比，游离铁量减少了2倍。用不含PA的培养基替代含PA的培养基可解除PA的阻断作用。这伴随着细胞内游离铁量的完全恢复。细胞增殖的调节可能与细胞内游离铁含量相关。
