CirTech Institute, HUTECH University, Ho Chi Minh City, Vietnam.
Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam.
Nat Prod Res. 2024 Aug;38(15):2609-2613. doi: 10.1080/14786419.2023.2193893. Epub 2023 Mar 27.
A new carvotacetone sphaeranthone A and four known compounds 3-angeloyloxy-5-[2″,3″-epoxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (), 3-angeloyloxy-5-[3″-chloro-2″-hydroxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (), chrysosplenol D (), and 3--methylquercetin () were isolated from leaves of growing in Vietnam. Their chemical structures were elucidated by extensive 1D and 2D NMR analysis and high-resolution mass spectroscopy as well as comparisons in literature. Compounds were evaluated for the alpha-glucosidase inhibition. They showed moderate activity with IC values of 103 ± 1.7, 146.8 ± 2.5, 49 ± 0.8 µg/mL, respectively.
从越南产的 中分离得到了一个新的 carvotacetone sphaeranthone A 和四个已知化合物 3-angeloyloxy-5-[2″,3″-epoxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (), 3-angeloyloxy-5-[3″-chloro-2″-hydroxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (), chrysosplenol D (), 和 3--methylquercetin ()。通过广泛的 1D 和 2D NMR 分析、高分辨率质谱以及文献比较,阐明了它们的化学结构。对化合物 进行了 α-葡萄糖苷酶抑制活性评价。它们的 IC 值分别为 103±1.7、146.8±2.5、49±0.8μg/mL,表现出中等的活性。