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球兰 A,一种从. 的叶子中分离得到的新的开环二萜酮。

Sphaeranthone A, a new carvotacetone from the leaves of .

机构信息

CirTech Institute, HUTECH University, Ho Chi Minh City, Vietnam.

Department of Chemistry, Ho Chi Minh City University of Education, Ho Chi Minh City, Vietnam.

出版信息

Nat Prod Res. 2024 Aug;38(15):2609-2613. doi: 10.1080/14786419.2023.2193893. Epub 2023 Mar 27.

Abstract

A new carvotacetone sphaeranthone A and four known compounds 3-angeloyloxy-5-[2″,3″-epoxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (), 3-angeloyloxy-5-[3″-chloro-2″-hydroxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (), chrysosplenol D (), and 3--methylquercetin () were isolated from leaves of growing in Vietnam. Their chemical structures were elucidated by extensive 1D and 2D NMR analysis and high-resolution mass spectroscopy as well as comparisons in literature. Compounds were evaluated for the alpha-glucosidase inhibition. They showed moderate activity with IC values of 103 ± 1.7, 146.8 ± 2.5, 49 ± 0.8 µg/mL, respectively.

摘要

从越南产的 中分离得到了一个新的 carvotacetone sphaeranthone A 和四个已知化合物 3-angeloyloxy-5-[2″,3″-epoxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (), 3-angeloyloxy-5-[3″-chloro-2″-hydroxy-2″-methylbutanoyloxy]-7-hydroxycarvotacetone (), chrysosplenol D (), 和 3--methylquercetin ()。通过广泛的 1D 和 2D NMR 分析、高分辨率质谱以及文献比较,阐明了它们的化学结构。对化合物 进行了 α-葡萄糖苷酶抑制活性评价。它们的 IC 值分别为 103±1.7、146.8±2.5、49±0.8μg/mL,表现出中等的活性。

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