N-钙黏蛋白表达与鼻咽癌患者颈部淋巴结转移的关系
N-Cadherin Expression with Metastasis of Neck Lymph Nodes in Patients with Nasopharyngeal Carcinoma.
作者信息
Yusuf Muhtarum, Pradana Yogi Putra Adhi, Rahmawati Rosydiah, Farhat Farhat, Kusumastuti Etty Hary, Ekoputro Jeffi Wahyu
机构信息
Department of Otorhinolaryngology, Head, and Neck Surgery, Airlangga University, Surabaya, East Java, Indonesia.
Department of Otorhinolaryngology, Head, and Neck Surgery, Dr. Soetomo General Teaching Hospital, Surabaya, East Java, Indonesia.
出版信息
Int J Gen Med. 2023 Mar 21;16:1029-1037. doi: 10.2147/IJGM.S393863. eCollection 2023.
BACKGROUND
Lymph node (LN) metastases were one characteristic of negative progress of NPC patient despite its advanced therapeutic approaches. One mechanism for the occurrence of epithelial to mesenchymal transition (EMT)-mediated metastases is by increasing N-cadherin expression. The purpose of this research is to determine investigating N-cadherin expression against metastatic LN in NPC cases.
METHODS
Samples were taken by unproportionate stratified random sampling. N-cadherin expression was examined using immunohistochemistry methods. N-cadherin expression was assessed visually by binocular light microscopy. We analyzed these data using Mann-Whitney -test to examine N-cadherin expression and lymph node metastases.
RESULTS
A strong expression was found in N3 group by 63.6%; 27.3% in the N2 group and 9.1% in the N1 group. In patients with NPC N0 or without lymph node metastases, N-cadherin expression is 0%. The expression of N-cadherin is indeed an indicator of the occurrence of lymph node metastases in NPC with a statistically significant analysis of p = 0.026 (p < 0.05).
CONCLUSION
There were correlations between N-cadherin expression and lymph node metastasis on NPC patients.
背景
尽管鼻咽癌患者有先进的治疗方法，但淋巴结转移仍是其病情进展不利的一个特征。上皮-间质转化（EMT）介导的转移发生的一种机制是通过增加N-钙黏蛋白的表达。本研究的目的是确定在鼻咽癌病例中研究N-钙黏蛋白表达与转移性淋巴结的关系。
方法
采用非比例分层随机抽样采集样本。使用免疫组织化学方法检测N-钙黏蛋白的表达。通过双目光学显微镜直观评估N-钙黏蛋白的表达。我们使用Mann-Whitney检验分析这些数据，以检查N-钙黏蛋白表达与淋巴结转移情况。
结果
N3组中发现强表达的占63.6%；N2组为27.3%，N1组为9.1%。在鼻咽癌N0或无淋巴结转移的患者中，N-钙黏蛋白表达为0%。N-钙黏蛋白的表达确实是鼻咽癌发生淋巴结转移的一个指标，经统计学分析p = 0.026（p < 0.05），具有统计学意义。
结论
鼻咽癌患者中N-钙黏蛋白表达与淋巴结转移之间存在相关性。
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