Attoh-Mensah Elpidio, Igor-Gaez Ivan, Vincent Lydie, Bessot Nicolas, Nathou Clément, Etard Olivier
Normandie Université, UNICAEN, INSERM, COMETE, CYCERON, CHU de Caen, 14000, Caen, France.
Neurobiol Sleep Circadian Rhythms. 2023 Mar 16;14:100093. doi: 10.1016/j.nbscr.2023.100093. eCollection 2023 May.
The autonomic nervous system (ANS) and the central nervous system (CNS) interplay during sleep, particularly during phasic events such as micro-arousals, has been the subject of several studies. The underlying mechanisms of such relationship which remain unclear, specifically during daytime sleep, were partly investigated in this study. Napping polysomnography was performed on two occasions at least one week apart in 15 healthy subjects. The following cardiorespiratory variables were extracted from the recordings: tachogram, pulse transit time (PTT), pulse wave amplitude, respiratory cycle amplitude, and frequency. Two experts first detected micro-arousal events, then, cardiorespiratory variables were averaged by 30-s epochs over 2 min centered on the onset of the micro-arousals. We found that in the 30 s preceding the arousal events as detected on the electroencephalogram (EEG) recordings, there was a decrease in tachogram, pulse wave amplitude, and PTT values while the respiratory amplitude increased. These changes were more prominent in stage N2 and N3 sleep than in stage N1. The present findings provide new insights into the autonomic changes during the pre-arousal period in daytime naps, as all the variables investigated suggest a sympathetic physiological origin for the changes.
自主神经系统（ANS）与中枢神经系统（CNS）在睡眠期间，尤其是在微觉醒等阶段性事件期间相互作用，这已成为多项研究的主题。这种关系的潜在机制尚不清楚，特别是在日间睡眠期间，本研究对此进行了部分调查。对15名健康受试者进行了两次至少间隔一周的午睡多导睡眠图检查。从记录中提取了以下心肺变量：心动图、脉搏传输时间（PTT）、脉搏波振幅、呼吸周期振幅和频率。两位专家首先检测微觉醒事件，然后，以微觉醒开始为中心，在2分钟内以30秒为时间段对心肺变量进行平均。我们发现，在脑电图（EEG）记录中检测到的觉醒事件前30秒，心动图、脉搏波振幅和PTT值下降，而呼吸振幅增加。这些变化在N2和N3睡眠阶段比在N1阶段更明显。本研究结果为日间午睡觉醒前期的自主神经变化提供了新的见解，因为所有研究变量均表明这些变化具有交感神经生理起源。
