Institute of Social Medicine and Health Systems Research, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany.
University of Regensburg, Regensburg, Germany.
Pediatr Allergy Immunol. 2023 Mar;34(3):e13934. doi: 10.1111/pai.13934.
A systematic review on measurement properties of patient-reported outcome measures (PROMs) for the assessment of quality of life (QoL) in children and adults with eczema was published in 2016 and updated in 2019. We now aimed to systematically assess the measurement properties of PROMs based on recently published development and validation studies regarding quality-of-life skin- or disease-specific PROMs using the COnsensus-based Standards for the selection of health Measurement Instruments (COSMIN) guidelines and integrate these findings with those from the 2019 update. A systematic literature search was conducted in PubMed and Embase. Eligible studies reported on measurement properties of QoL skin- or disease-specific PROMs for the assessment of QoL in children and adults with eczema. The methodological quality of the included studies was evaluated using the COSMIN Risk of Bias checklist. The methodological quality of the included PROMs was judged using updated criteria for good measurement properties, and the quality of evidence was graded. The new evidence was integrated into the results from the 2019 update. Finally, a recommendation for use of the identified PROMs was derived based on all evidence. We identified 12 studies fulfilling our inclusion criteria. Based on the newly generated evidence, the Childhood Atopic Dermatitis Impact Scale-short form (CADIS-SF) for infants and the Skindex for adults can be recommended for use. We identified three new PROMs, which have the potential to be used, but require further validation: the Pediatric Allergic Disease Quality of Life Questionnaire (PADQLQ), the Skindex-Mini, and the Scratch Intensity and Impact Scale (SIIS). All other assessed PROMs still have the opportunity to be recommended for use (except for the Dermatology Life Quality Index (DLQI)) but need further validation. Currently, two PROMs for the assessment of QoL in eczema can be recommended for use: the CADIS-SF for infants and the Skindex for adults. Many PROMs, including the recently developed and/or validated PROMs PADQLQ, Skindex-Mini and SIIS, need further validation.
一篇关于评估湿疹患儿和成人生活质量（QoL）的患者报告结局测量（PROM）的测量特性的系统评价于 2016 年发表，并于 2019 年更新。我们旨在根据最近发表的关于基于皮肤或疾病特异性 PROM 的生活质量的开发和验证研究，使用共识基础的健康测量仪器选择标准（COSMIN）指南系统地评估 PROM 的测量特性，并将这些发现与 2019 年更新的内容相结合。在 PubMed 和 Embase 中进行了系统的文献检索。合格的研究报告了用于评估湿疹患儿和成人生活质量的皮肤或疾病特异性 PROM 的 QoL 测量特性。使用 COSMIN 偏倚风险检查表评估纳入研究的方法学质量。使用更新的良好测量特性标准判断纳入 PROM 的方法学质量，并对证据质量进行分级。将新证据纳入 2019 年更新的结果中。最后，根据所有证据得出了对确定的 PROM 的使用建议。我们确定了符合纳入标准的 12 项研究。基于新生成的证据，可以推荐使用婴儿的儿童特应性皮炎影响量表-简表（CADIS-SF）和成人的 Skindex。我们确定了三种具有潜在应用价值但需要进一步验证的新 PROM：儿科过敏性疾病生活质量问卷（PADQLQ）、Skindex-Mini 和划痕强度和影响量表（SIIS）。所有其他评估的 PROM 仍然有机会被推荐使用（除了皮肤病生活质量指数（DLQI）之外），但需要进一步验证。目前，有两种用于评估湿疹患者生活质量的 PROM 可以推荐使用：婴儿的 CADIS-SF 和成人的 Skindex。许多 PROM，包括最近开发和/或验证的 PROM，如 PADQLQ、Skindex-Mini 和 SIIS，需要进一步验证。
