Medical Sociology, Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany.
VU University Medical Center, Department of Epidemiology and Biostatistics, EMGO+ Institute for Health and Care Research, Amsterdam, The Netherlands.
Allergy. 2016 Mar;71(3):358-70. doi: 10.1111/all.12806. Epub 2015 Dec 16.
The Harmonising Outcome Measures for Eczema (HOME) initiative has identified quality of life (QoL) as a core outcome domain to be evaluated in every eczema trial. It is unclear which of the existing QoL instruments is most appropriate for this domain. Thus, the aim of this review was to systematically assess the measurement properties of existing measurement instruments developed and/or validated for the measurement of QoL in adult eczema.
We conducted a systematic literature search in PubMed and Embase identifying studies on measurement properties of adult eczema QoL instruments. For all eligible studies, we assessed the adequacy of the measurement properties and the methodological quality with the COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) checklist. A best evidence synthesis summarizing findings from different studies was the basis to assign four degrees of recommendation (A-D).
A total of 15 articles reporting on 17 instruments were included. No instrument fulfilled the criteria for category A. Six instruments were placed in category B, meaning that they have the potential to be recommended depending on the results of further validation studies. Three instruments had poor adequacy in at least one required adequacy criterion and were therefore put in category C. The remaining eight instruments were minimally validated and were thus placed in category D.
Currently, no QoL instrument can be recommended for use in adult eczema. The Quality of Life Index for Atopic Dermatitis (QoLIAD) and the Dermatology Life Quality Index (DLQI) are recommended for further validation research.
湿疹结局测量协调倡议（HOME）已经确定生活质量（QoL）是每个湿疹试验都需要评估的核心结果领域。目前尚不清楚哪种现有的 QoL 工具最适合该领域。因此，本研究旨在系统评估已开发和/或验证用于测量成人湿疹 QoL 的现有测量工具的测量特性。
我们在 PubMed 和 Embase 中进行了系统文献检索，以确定关于成人湿疹 QoL 工具测量特性的研究。对于所有合格的研究，我们使用共识基础的健康测量工具选择标准（COSMIN）清单评估测量特性和方法学质量的充分性。总结不同研究结果的最佳证据综合是为推荐分配四个推荐等级（A-D）的基础。
共纳入 15 篇报告 17 种工具的文章。没有一种工具符合类别 A 的标准。6 种工具被归类为 B 类，这意味着它们有可能根据进一步验证研究的结果被推荐。有 3 种工具在至少一个必需的充分性标准上存在不足，因此被归类为 C 类。其余 8 种工具的验证程度较差，因此被归类为 D 类。
目前，没有任何 QoL 工具可推荐用于成人湿疹。推荐对过敏性皮炎生活质量指数（QoLIAD）和皮肤病生活质量指数（DLQI）进行进一步的验证研究。
