Department of Neurology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Institute of Virology, Charité-Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany/German Centre for Infection Research (DZIF), Berlin, Germany.
Mult Scler. 2023 Jun;29(7):884-888. doi: 10.1177/13524585231161253. Epub 2023 Mar 28.
To analyze anti-SARS-CoV-2-S1-IgG levels, avidity, Omicron BA.2 variant neutralizing capacity, and SARS-CoV-2-specific T cells in anti-CD20-treated patients with multiple sclerosis (aCD20pwMS) after two, three, or four COVID-19 vaccinations.
Frequencies of aCD20pwMS with detectable SARS-CoV-2-S1-IgG increased moderately between two (31/61 (51%)), three (31/57 (54%)), and four (17/26 (65%)) vaccinations. However, among patients with detectable SARS-CoV-2-S1-IgG, frequencies of high avidity (6/31 (19%) vs 11/17 (65%)) and Omicron neutralizing antibodies (0/10 (0%) vs 6/10 (60%)) increased strongly between two and four vaccinations. SARS-CoV-2-specific T cells were detectable in >92% after two or more vaccinations.
Additional vaccinations qualitatively improve SARS-CoV-2 antibody responses.
分析接受抗 CD20 治疗的多发性硬化症患者（aCD20pwMS）在接种两针、三针或四针 COVID-19 疫苗后，针对 SARS-CoV-2-S1-IgG 的水平、亲和力、Omicron BA.2 变异体中和能力以及 SARS-CoV-2 特异性 T 细胞。
在两针（31/61（51%））、三针（31/57（54%））和四针（17/26（65%））疫苗接种之间，检测到 SARS-CoV-2-S1-IgG 的 aCD20pwMS 频率适度增加。然而，在检测到 SARS-CoV-2-S1-IgG 的患者中，高亲和力（6/31（19%）与 11/17（65%））和 Omicron 中和抗体（0/10（0%）与 6/10（60%））的频率在两针和四针之间强烈增加。在接种两针或更多针疫苗后，超过 92%的患者可检测到 SARS-CoV-2 特异性 T 细胞。
额外的疫苗接种可在质量上改善 SARS-CoV-2 抗体反应。
