突发性聋与内皮祖细胞和脂蛋白相关磷脂酶 A2 有关。
Sudden Sensorineural Hearing Loss Is Related to Endothelial Progenitor Cells and Lipoprotein-Associated Phospholipase A2.
机构信息
Department of Otolaryngology, General Hospital of Tianjin Medical University, Tianjin, China.
Department of Otolaryngology, Beijing Tsinghua Changgung Hospital, Tsinghua University, Beijing, China.
出版信息
J Int Adv Otol. 2023 Mar;19(2):76-80. doi: 10.5152/iao.2023.21523.
BACKGROUND
This study aimed to investigate the correlation between lipoprotein-associated phospholipase A2, endothelial progenitor cells, and sudden sensorineural hearing loss.
METHODS
The number of endothelial progenitor cells and lipoprotein-associated phospholipase A2 levels collected from peripheral blood samples were measured and compared between sudden sensorineural hearing loss group and control group.
RESULTS
The number of endothelial progenitor cells was reduced in sudden sensorineural hearing loss group compared to control group (38.88 ± 10.73 in sudden sensorineural hearing loss group vs. 77.14 ± 8.56 in control group, P <.01). The lipoprotein-associated phospholipase A2 level was markedly increased in sudden sensorineural hearing loss group compared to control group (244.94 ± 59.547 in sudden sensorineural hearing loss group vs. 189.00 ± 50.987 in control group, P <.05).
CONCLUSION
The number of endothelial progenitor cells was decreased and lipoprotein-associated phospholipase A2 levels were increased in sudden sensorineural hearing loss patients. Changes in the number of endothelial progenitor cells and lipoprotein-associated phospholipase A2 levels may be involved in the pathogenesis of sudden sensorineural hearing loss.
背景
本研究旨在探讨脂蛋白相关磷脂酶 A2（Lp-PLA2）、内皮祖细胞与突发性聋之间的相关性。
方法
收集外周血样，测量并比较突发性聋组和对照组的内皮祖细胞数量和脂蛋白相关磷脂酶 A2 水平。
结果
与对照组相比，突发性聋组内皮祖细胞数量减少（突发性聋组 38.88±10.73，对照组 77.14±8.56，P<.01）。脂蛋白相关磷脂酶 A2 水平在突发性聋组明显升高（突发性聋组 244.94±59.547，对照组 189.00±50.987，P<.05）。
结论
突发性聋患者的内皮祖细胞数量减少，脂蛋白相关磷脂酶 A2 水平升高。内皮祖细胞数量和脂蛋白相关磷脂酶 A2 水平的变化可能参与了突发性聋的发病机制。
Zotero 插件