Colagrande Anna, Ingravallo Giuseppe, Cazzato Gerardo
Section of Molecular Pathology, Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), University of Bari "Aldo Moro", 70124 Bari, Italy.
Dermatopathology (Basel). 2023 Mar 22;10(1):120-127. doi: 10.3390/dermatopathology10010018.
Traditionally, the term melanoma in situ (MIS) is used to designate a horizontal (radial) growth phase of malignant melanoma (MM) in which there is no histological evidence of any invasion (or microinvasion) of neoplastic melanocytic cells into the superficial or papillary dermis. In daily dermatopathological practice, we are faced with misleading definitions, such as "melanoma in situ with regression," which risk affecting homogeneity for comparison purposes of pathological reports of malignant melanoma. The authors conducted a literature review using PubMed and Web of Science (WoS) as the main databases and using the following keywords: "Malignant Melanoma in situ" or "Melanoma in situ" and "regression" and/or "radial growth phase regression." A total of 213 articles from both analyzed databases were retrieved; finally, only eight articles in English were considered suitable for the chosen inclusion criteria. In consideration of the absence of studies with large case series, of reviews with meta-analyses, and, therefore, of a broad scientific consensus, expressions including "melanoma in situ with regression" should be avoided in the histopathological report. Instead, they should be replaced with clearer and more exhaustive definitions.
传统上，原位黑色素瘤（MIS）一词用于指恶性黑色素瘤（MM）的水平（放射状）生长阶段，在此阶段，肿瘤性黑素细胞没有任何侵入（或微侵袭）到浅表或乳头层真皮的组织学证据。在日常皮肤病理学实践中，我们面临一些误导性定义，例如“伴有消退的原位黑色素瘤”，这可能会影响恶性黑色素瘤病理报告比较的同质性。作者以PubMed和科学网（WoS）作为主要数据库进行了文献综述，使用了以下关键词：“原位恶性黑色素瘤”或“原位黑色素瘤”以及“消退”和/或“放射状生长阶段消退”。从两个分析数据库中总共检索到213篇文章；最后，仅八篇英文文章被认为符合选定的纳入标准。鉴于缺乏大病例系列研究、荟萃分析综述，因此缺乏广泛的科学共识，在组织病理学报告中应避免使用包括“伴有消退的原位黑色素瘤”在内的表述。相反，它们应以更清晰、更详尽的定义取而代之。
