Department of Surgery, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705 Kraków, Poland.
Department of General, Oncological and Vascular Surgery, 5th Military Clinical Hospital in Kraków, 30-901 Kraków, Poland.
Curr Oncol. 2023 Mar 14;30(3):3366-3372. doi: 10.3390/curroncol30030256.
To date, there have been multiple studies and clinical guidelines or recommendations for complex management of melanoma patients. The most controversial subjects included the frequency of follow-up. This study provides a coherent and comprehensive comparison of conventional vs. reduced-frequency follow-up strategies for early-stage melanoma patients. The value of our study consists in the precise analysis of a large collection of articles and the selection of the most valuable works in relation to the topic according to rigorous criteria, which allowed for a thorough study of the topic. The search strategy was implemented using multiple databases. The inclusion criteria were randomized clinical trial or cohort studies that compared the outcomes of a conventional follow-up schedule versus a reduced-frequency follow-up schedule for patients diagnosed with melanoma. In this study, authors analyzed recurrence and 3-year survival. Meta-analysis of outcomes presented by Deckers et al. and Moncrieff et. al. did not reveal a significant difference favoring one of the groups (OR 1.14; 95%CI: 0.65-2.00; = 0.64). The meta-analysis of 3-year overall survival included two studies. The statistical analysis showed no significant difference in favor of the conventional follow-up group. (OR 1.10; 95%CI: 0.57-2.11; = 0.79). Our meta-analysis shows that there is no advantage in a conventional follow-up regimen over a reduced-frequency regimen in early-stage melanoma patients.
迄今为止，已经有多项研究和临床指南或建议针对黑色素瘤患者的复杂管理。最具争议的主题包括随访的频率。本研究对早期黑色素瘤患者的常规随访策略与降低频率随访策略进行了连贯而全面的比较。我们的研究价值在于对大量文献进行了精确分析，并根据严格的标准选择了与主题相关的最有价值的作品，从而对该主题进行了深入研究。搜索策略使用了多个数据库。纳入标准是比较常规随访计划与降低频率随访计划对诊断为黑色素瘤的患者的结果的随机临床试验或队列研究。在这项研究中，作者分析了复发和 3 年生存率。Deckers 等人和 Moncrieff 等人的结果荟萃分析并未发现有利于其中任何一组的显著差异（OR 1.14；95%CI：0.65-2.00； = 0.64）。包括两项研究的 3 年总生存率的荟萃分析显示，常规随访组没有明显的优势。（OR 1.10；95%CI：0.57-2.11； = 0.79）。我们的荟萃分析表明，在早期黑色素瘤患者中，常规随访方案并不优于降低频率的方案。
