ParticleChromo3D+：用于三维染色体结构重建的ParticleChromo3D算法的网络服务器。

ParticleChromo3D+: A Web Server for ParticleChromo3D Algorithm for 3D Chromosome Structure Reconstruction.

作者信息

Vadnais David, Oluwadare Oluwatosin

机构信息

Department of Computer Science, University of Colorado, Colorado Springs, CO 80918, USA.

出版信息

Curr Issues Mol Biol. 2023 Mar 17;45(3):2549-2560. doi: 10.3390/cimb45030167.

DOI:10.3390/cimb45030167

PMID:36975537

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10046902/

Abstract

Understanding the three-dimensional (3D) structure of chromatin is invaluable for researching how it functions. One way to gather this information is the chromosome conformation capture (3C) technique and its follow-up technique Hi-C. Here, we present ParticleChromo3D+, a containerized web-based genome structure reconstruction server/tool that provides researchers with a portable and accurate tool for analyses. Additionally, ParticleChromo3D+ provides a more user-friendly way to access its capabilities via a graphical user interface (GUI). ParticleChromo3D+ can save time for researchers by increasing the accessibility of genome reconstruction, easing usage pain points, and offloading computational processing/installation time.

摘要

了解染色质的三维（3D）结构对于研究其功能非常重要。获取这些信息的一种方法是染色体构象捕获（3C）技术及其后续技术Hi-C。在此，我们展示了ParticleChromo3D+，这是一个基于容器的网络化基因组结构重建服务器/工具，为研究人员提供了一个便携且准确的分析工具。此外，ParticleChromo3D+通过图形用户界面（GUI）提供了一种更用户友好的方式来访问其功能。ParticleChromo3D+可以通过提高基因组重建的可及性、缓解使用痛点以及减少计算处理/安装时间，为研究人员节省时间。