Maurya Sujata, Srivastava Rashi, Arfin Saniya, Hawthorne Susan, Jha Niraj Kumar, Agrawal Kirti, Raj Sibi, Rathi Brijesh, Kumar Arun, Raj Riya, Agrawal Sharad, Paiva-Santos Ana Cláudia, Malik Asrar Ahmad, Dua Kamal, Rana Rakesh, Ojha Shreesh, Jha Saurabh Kumar, Sharma Ankur, Kumar Dhruv, El-Zahaby Sally A, Nagar Amka
School of Health Sciences & Technology, UPES University, Dehradun, Uttarakhand, 248007, India.
Chemical & Biochemical Engineering, Indian Institute of Technology, Patna, 801106, India.
Nanomedicine (Lond). 2022 Dec;17(30):2245-2264. doi: 10.2217/nnm-2021-0437. Epub 2023 Mar 28.
Diagnosis and treatment of lung diseases pose serious challenges. Currently, diagnostic as well as therapeutic methods show poor efficacy toward drug-resistant bacterial infections, while chemotherapy causes toxicity and nonspecific delivery of drugs. Advanced treatment methods that cure lung-related diseases, by enabling drug bioavailability via nasal passages during mucosal formation, which interferes with drug penetration to targeted sites, are in demand. Nanotechnology confers several advantages. Currently, different nanoparticles, or their combinations, are being used to enhance targeted drug delivery. Nanomedicine, a combination of nanoparticles and therapeutic agents, that delivers drugs to targeted sites increases the bioavailability of drugs at these sites. Thus, nanotechnology is superior to conventional chemotherapeutic strategies. Here, the authors review the latest advancements in nanomedicine-based drug-delivery methods for managing acute and chronic inflammatory lung diseases.
肺部疾病的诊断和治疗面临严峻挑战。目前，诊断和治疗方法对耐药细菌感染的疗效不佳，而化疗会产生毒性且药物递送缺乏特异性。人们需要先进的治疗方法，通过在黏膜形成过程中使药物经鼻腔途径实现生物利用度，从而治愈肺部相关疾病，但这会干扰药物渗透到靶向部位。纳米技术具有诸多优势。目前，不同的纳米颗粒或其组合正被用于增强靶向药物递送。纳米医学是纳米颗粒与治疗剂的结合，可将药物递送至靶向部位，提高这些部位药物的生物利用度。因此，纳米技术优于传统化疗策略。在此，作者综述了基于纳米医学的药物递送方法在治疗急慢性炎症性肺部疾病方面的最新进展。
