Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Division of Nephrology and Hypertension, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Physiology (Bethesda). 2023 Jul 1;38(4):0. doi: 10.1152/physiol.00031.2022. Epub 2023 Mar 28.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) inflammatory pathway is a component of the innate immune system that recognizes cytosolic nucleic acids. The pathway has been implicated in several processes including aging, autoinflammatory conditions, cancer, and metabolic diseases. The cGAS-STING pathway represents a promising therapeutic target in a variety of chronic inflammatory diseases.
环鸟苷酸-腺苷酸合成酶 (cGAS)-干扰素基因刺激蛋白 (STING) 炎症途径是先天免疫系统的一个组成部分，可识别细胞溶质核酸。该途径与包括衰老、自身炎症性疾病、癌症和代谢疾病在内的多种过程有关。cGAS-STING 途径是多种慢性炎症性疾病有前途的治疗靶点。
