Ratcliffe G E, Cooke S, Fogelman I, Maisey M N
Br J Radiol. 1986 Apr;59(700):385-7. doi: 10.1259/0007-1285-59-700-385.
Forty-eight patients with hyperthyroidism due to a single toxic nodule have been treated with radioiodine (131I). The mean follow-up period is 37 months. All patients were rendered euthyroid and no cases of hyperthyroidism have been observed. Forty patients required only one dose of 131I to render them euthyroid, six patients required more than one dose and two patients initially rendered euthyroid relapsed during follow-up and required further 131I treatment. It is concluded that a single fixed dose of 131I is a simple, effective treatment for a solitary toxic thyroid nodule and does not cause hypothyroidism.
48例因单一毒性结节导致甲状腺功能亢进的患者接受了放射性碘（131I）治疗。平均随访期为37个月。所有患者均恢复为甲状腺功能正常，未观察到甲状腺功能亢进病例。40例患者仅需一剂131I即可恢复甲状腺功能正常，6例患者需要一剂以上，2例最初恢复甲状腺功能正常的患者在随访期间复发，需要进一步接受131I治疗。结论是，单一固定剂量的131I是治疗孤立性毒性甲状腺结节的一种简单、有效的方法，且不会导致甲状腺功能减退。
