Airapetov M I, Eresko S O, Ignatova P D, Lebedev A A, Bychkov E R, Shabanov P D
Department of Pharmacology, St. Petersburg State Pediatric Medical University, St. Petersburg, 194044 Russia.
Department of Neuropharmacology, Institute of Experimental Medicine, St. Petersburg, 197022 Russia.
Mol Biol (Mosk). 2023 Jan-Feb;57(1):3-9. doi: 10.31857/S0026898423010020.
The study of the role of cytokines in various pathological conditions of the body is a topical area in modern biomedicine. Understanding the physiological roles played by cytokines will aid in finding applications for them as pharmacological agents in clinical practice. Interleukin 11 (IL-11) was discovered in 1990 in fibrocyte-like bone marrow stromal cells, but there has been increased interest in this cytokine in recent years. IL-11 has been shown to correct inflammatory pathways in the epithelial tissues of the respiratory system, where the main events occur during SARS-CoV-2 infection. Further research in this direction will probably support the use of this cytokine in clinical practice. The cytokine plays a significant role in the central nervous system; local expression by nerve cells has been shown. Studies show the involvement of IL-11 in the mechanisms of development of a number of pathologies of the nervous system, and therefore it seems relevant to generalize and analyze the experimental data obtained in this direction. This review summarizes information that shows the involvement of IL-11 in the mechanisms of development of brain pathologies. In the near future this cytokine will likely find clinical application for the correction of mechanisms that are involved in the formation of pathological conditions of the nervous system.
细胞因子在机体各种病理状态中的作用研究是现代生物医学的一个热门领域。了解细胞因子所发挥的生理作用将有助于在临床实践中找到它们作为药物制剂的应用。白细胞介素11（IL-11）于1990年在类成纤维细胞的骨髓基质细胞中被发现，但近年来人们对这种细胞因子的兴趣有所增加。IL-11已被证明可纠正呼吸系统上皮组织中的炎症途径，而严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染时的主要病变就发生在该系统。在这个方向上的进一步研究可能会支持在临床实践中使用这种细胞因子。该细胞因子在中枢神经系统中发挥着重要作用；已证实神经细胞可进行局部表达。研究表明IL-11参与了多种神经系统疾病的发病机制，因此总结和分析这一方向上获得的实验数据似乎很有必要。这篇综述总结了表明IL-11参与脑部疾病发病机制的信息。在不久的将来，这种细胞因子可能会在纠正参与神经系统病理状态形成的机制方面找到临床应用。
