Advanced Targeting Systems, Inc., Carlsbad, CA 92011, USA.
Toxins (Basel). 2023 Feb 27;15(3):181. doi: 10.3390/toxins15030181.
Streptavidin-Saporin can be considered a type of 'secondary' targeted toxin. The scientific community has taken advantage of this conjugate in clever and fruitful ways using many kinds of biotinylated targeting agents to send saporin into a cell selected for elimination. Saporin is a ribosome-inactivating protein that causes inhibition of protein synthesis and cell death when delivered inside a cell. Streptavidin-Saporin, mixed with biotinylated molecules to cell surface markers, results in powerful conjugates that are used both in vitro and in vivo for behavior and disease research. Streptavidin-Saporin harnesses the 'Molecular Surgery' capability of saporin, creating a modular arsenal of targeted toxins used in applications ranging from the screening of potential therapeutics to behavioral studies and animal models. The reagent has become a well-published and validated resource in academia and industry. The ease of use and diverse functionality of Streptavidin-Saporin continues to have a significant impact on the life science industry.
链霉亲和素-苏旦可以被认为是一种“二级”靶向毒素。科学界已经利用这种缀合物，通过使用许多种生物素化的靶向剂将苏旦送入选定用于消除的细胞，以巧妙而富有成效的方式加以利用。苏旦是一种核糖体失活蛋白，当递送到细胞内时会导致蛋白质合成抑制和细胞死亡。链霉亲和素-苏旦与细胞表面标志物的生物素化分子混合，产生强大的缀合物，用于体外和体内行为和疾病研究。链霉亲和素-苏旦利用苏旦的“分子手术”能力，创建了一个模块化的靶向毒素库，用于从筛选潜在治疗药物到行为研究和动物模型等各种应用。该试剂已成为学术界和工业界广泛发表和验证的资源。链霉亲和素-苏旦的易用性和多功能性继续对生命科学行业产生重大影响。
