DaVanzo J P, Chamberlain J K, Garris D R, Swanson M S
Brain Res. 1986 Mar 26;369(1-2):224-30. doi: 10.1016/0006-8993(86)90531-7.
Male mice which are housed individually develop a characteristic aggressive, 'fighting' behavior. A small percentage of mice so isolated fail to become aggressive and in fact, behaviorally are strikingly different in that they develop a 'timid' behavior. Isolation-induced aggression is an androgen-dependent behavior and androgen-sensitive neurons have been identified in mouse brain, mainly in the limbic system. When intact isolated aggressive mice and isolated and aggregated non-aggressive mice were injected with radioactive testosterone and sacrificed after 30 min no remarkable differences in uptake of radioactive testosterone occurred in various brain areas. However, in castrated animals the uptake of testosterone was greatly enhanced in the isolated non-fighters whereas testosterone uptake in the isolated fighters and aggregated non-fighters was in the range of the intact animals. This study represents, for the first time, a documented hormonal difference between isolated aggressive and non-aggressive animals.
单独饲养的雄性小鼠会表现出一种典型的攻击性“战斗”行为。一小部分如此隔离饲养的小鼠不会变得具有攻击性，事实上，它们在行为上有显著差异，会表现出“胆小”行为。隔离诱导的攻击行为是一种雄激素依赖性行为，并且在小鼠大脑中已鉴定出雄激素敏感神经元，主要位于边缘系统。当给完整的隔离攻击性小鼠以及隔离且聚集的非攻击性小鼠注射放射性睾酮，并在30分钟后处死时，各个脑区对放射性睾酮的摄取没有显著差异。然而，在去势动物中，隔离的非战斗小鼠对睾酮的摄取大大增强，而隔离的战斗小鼠和聚集的非战斗小鼠对睾酮的摄取则处于完整动物的范围内。这项研究首次记录了隔离的攻击性动物和非攻击性动物之间的激素差异。
