Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, P. R. China.
Department of Medical Ultrasonic, Laboratory of Novel Optoacoustic (Ultrasonic) Imaging, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510630, P. R. China.
Adv Healthc Mater. 2023 Aug;12(20):e2203359. doi: 10.1002/adhm.202203359. Epub 2023 Apr 14.
Inhalation of xenon gas improves acute kidney injury (AKI). However, xenon can only be delivered through inhalation, which causes non-specific distribution and low bioavailability of xenon, thus limiting its clinical application. In this study, xenon is loaded into platelet membrane-mimicking hybrid microbubbles (Xe-Pla-MBs). In ischemia-reperfusion-induced AKI, intravenously injected Xe-Pla-MBs adhere to the endothelial injury site in the kidney. Xe-Pla-MBs are then disrupted by ultrasound, and xenon is released to the injured site. This release of xenon reduced ischemia-reperfusion-induced renal fibrosis and improved renal function, which are associated with decreased protein expression of cellular senescence markers p53 and p16, as well as reduced beta-galactosidase in renal tubular epithelial cells. Together, platelet membrane-mimicking hybrid microbubble-delivered xenon to the injred site protects against ischemia-reperfusion-induced AKI, which likely reduces renal senescence. Thus, the delivery of xenon by platelet membrane-mimicking hybrid microbubbles is a potential therapeutic approach for AKI.
氙气吸入可改善急性肾损伤（AKI）。然而，氙气只能通过吸入方式给药，这导致氙气分布不均匀且生物利用度低，从而限制了其临床应用。在本研究中，氙气被载入血小板膜模拟混合微泡（Xe-Pla-MBs）中。在缺血再灌注诱导的 AKI 中，静脉注射的 Xe-Pla-MBs 会黏附在肾脏的内皮损伤部位。然后，超声会破坏 Xe-Pla-MBs，氙气会被释放到损伤部位。这种氙气的释放减少了缺血再灌注引起的肾纤维化，改善了肾功能，这与细胞衰老标志物 p53 和 p16 的蛋白表达减少以及肾小管上皮细胞中β-半乳糖苷酶减少有关。总之，血小板膜模拟混合微泡将氙气递送到损伤部位，可预防缺血再灌注引起的 AKI，可能减少肾脏衰老。因此，通过血小板膜模拟混合微泡输送氙气是治疗 AKI 的一种有潜力的方法。
