Veterinary Teaching Hospital/Faculty of Veterinary Medicine, University of de Lisbon, Lisbon, Portugal.
CIISA - Centre for Interdisciplinary Research in Animal Health - Faculty of Veterinary Medicine, University of Lisbon, Lisbon, Portugal.
J Small Anim Pract. 2023 Jun;64(6):415-420. doi: 10.1111/jsap.13601. Epub 2023 Mar 28.
Pheochromocytoma in cats is a rare clinical condition characterised by the development of a secretory endocrine tumour that arises from the adrenal medulla. An 8-year-old castrated male, domestic shorthair cat was referred for further investigation of a 4-month history of progressive weight loss with normal appetite, polyuria/polydipsia, generalised weakness, and severe hypertension. Sonography and computed tomography of the abdomen disclosed a mass arising from the left adrenal gland. The contralateral adrenal gland was normal in size and shape. Results from a low dose dexamethasone suppression test and measurements of plasma aldosterone concentration and plasma renin activity ruled out a cortisol-secreting tumour and aldosteronoma. The clinical presentation made a sex-steroid secreting tumour unlikely. Increased plasma metanephrine and normetanephrine concentrations prioritised the differential diagnosis of pheochromocytoma. The cat underwent adrenalectomy of the left gland and histopathological diagnosis with immunohistochemical markers confirmed the diagnosis.
猫的嗜铬细胞瘤是一种罕见的临床病症，其特征是发生源自肾上腺髓质的分泌性内分泌肿瘤。一只 8 岁已去势雄性、家短毛猫因进行性体重减轻 4 个月就诊，食欲正常，多尿/多饮，全身无力和严重高血压。腹部超声和 CT 显示左肾上腺有一个肿块。对侧肾上腺大小和形状正常。小剂量地塞米松抑制试验的结果以及醛固酮浓度和血浆肾素活性的测量排除了皮质醇分泌肿瘤和醛固酮瘤。临床表现不太可能是性甾体分泌肿瘤。血浆间甲肾上腺素和去甲肾上腺素浓度升高使嗜铬细胞瘤的鉴别诊断成为优先事项。猫接受了左肾上腺切除术，组织病理学诊断和免疫组织化学标志物证实了该诊断。
