Synuclein phosphorylation: pathogenic or physiologic?
作者信息
Kontaxi Christiana, Edwards Robert H
机构信息
UCSF School of Medicine, Departments of Neurology and Physiology, San Francisco, USA.
出版信息
NPJ Parkinsons Dis. 2023 Mar 28;9(1):47. doi: 10.1038/s41531-023-00487-z.
Abstract
摘要
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本文引用的文献
1
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity.动态生理性α-突触核蛋白S129磷酸化由神经元活动驱动。
NPJ Parkinsons Dis. 2023 Jan 16;9(1):4. doi: 10.1038/s41531-023-00444-w.
2
Phosphorylation induces distinct alpha-synuclein strain formation.磷酸化诱导形成不同的α-突触核蛋白构象。
Sci Rep. 2016 Nov 17;6:37130. doi: 10.1038/srep37130.
3
LK6/Mnk2a is a new kinase of alpha synuclein phosphorylation mediating neurodegeneration.LK6/Mnk2a是一种介导神经退行性变的α-突触核蛋白磷酸化的新型激酶。
Sci Rep. 2015 Jul 29;5:12564. doi: 10.1038/srep12564.
4
Ser129 phosphorylation of endogenous α-synuclein induced by overexpression of polo-like kinases 2 and 3 in nigral dopamine neurons is not detrimental to their survival and function.在黑质多巴胺神经元中过表达 Polo 样激酶 2 和 3 诱导的内源性 α-突触核蛋白 Ser129 磷酸化对其存活和功能没有损害。
Neurobiol Dis. 2015 Jun;78:100-14. doi: 10.1016/j.nbd.2015.03.008. Epub 2015 Mar 25.
5
Synucleins regulate the kinetics of synaptic vesicle endocytosis.突触核蛋白调节突触囊泡内吞的动力学。
J Neurosci. 2014 Jul 9;34(28):9364-76. doi: 10.1523/JNEUROSCI.4787-13.2014.
6
α-Synuclein disrupts stress signaling by inhibiting polo-like kinase Cdc5/Plk2.α-突触核蛋白通过抑制 Polo 样激酶 Cdc5/Plk2 破坏应激信号。
Proc Natl Acad Sci U S A. 2012 Oct 2;109(40):16119-24. doi: 10.1073/pnas.1206286109. Epub 2012 Sep 17.
7
α-synuclein phosphorylation and truncation are normal events in the adult human brain.α-突触核蛋白磷酸化和截断是成人脑中的正常事件。
Neuroscience. 2012 Jan 3;200:106-19. doi: 10.1016/j.neuroscience.2011.10.042. Epub 2011 Oct 29.
8
αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction.αβγ-突触核蛋白三敲除小鼠揭示了年龄依赖性神经元功能障碍。
Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19573-8. doi: 10.1073/pnas.1005005107. Epub 2010 Oct 25.
9
Alpha-synuclein promotes SNARE-complex assembly in vivo and in vitro.α-突触核蛋白在体内和体外促进 SNARE 复合物的组装。
Science. 2010 Sep 24;329(5999):1663-7. doi: 10.1126/science.1195227. Epub 2010 Aug 26.
10
Alpha-synuclein S129 phosphorylation mutants do not alter nigrostriatal toxicity in a rat model of Parkinson disease.α-突触核蛋白S129磷酸化突变体不会改变帕金森病大鼠模型中的黑质纹状体毒性。
J Neuropathol Exp Neurol. 2009 May;68(5):515-24. doi: 10.1097/NEN.0b013e3181a24b53.
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