血小板与淋巴细胞比值是佩特兹病的一个危险因素。
Platelet to lymphocyte ratio was a risk factor in Perthes disease.
机构信息
Department of Orthopedics, Ordos Central Hospital, 23 Ekin Hollow West Street, Ordos, 017000, China.
The First Affiliated Hospital of Guangxi Medical University, Nanning, 530000, China.
出版信息
Sci Rep. 2023 Mar 28;13(1):5052. doi: 10.1038/s41598-023-32000-0.
The study was aimed to determine the relationship between PLR (platelet to lymphocyte ratio) and the lateral pillar classification of Perthes disease, and to provide an alternative index for clinical diagnosis. In addition, the association of the PLR with the necrosis stage of Perthes disease was also explored. This was a retrospective study. 74 children with Perthes disease and 60 children in the healthy control group without femoral head necrosis in our hospital from 2012 to 2021 were collected. The general data and clinical parameters were collected from the hospital information system. The modified herring lateral pillar classification was collected for the fragmentation stage case group and the PLR, NLR (neutrophil to lymphocyte ratio), LMR (lymphocyte to monocyte ratio) and PNR (platelet to neutrophil ratio) were calculated. The cases were divided into four groups, herring A and B were group I, herring B/C and C were group II, the healthy control group was group III, and the necrosis stage was group IV. The hematological indexes (NLR, PLR, LMR, PNR) of children at different stages were statistically analyzed. Group I consisted of 36 patients, with an average age of 7.4 ± 2.0 years (3-11 years). Group II consisted of 23 patients, with an average age of 7.4 ± 1.9 years (4-12 years). Group III consisted of 60 patients, with a mean age of 7.4 ± 2.7 years (4-13 years). Group IV consisted of 15 patients, with an average age of 6.4 ± 1.7 years (3-10 years). The average values of PLR in groups I, II, III and IV were 131.98 ± 47.44, 122.19 ± 37.88, 102.46 ± 30.68 and 128.90 ± 28.11, respectively. It's worth noting that there was statistically significant difference among groups I, II and III (P = 0.003). The optimal threshold of PLR was 130.25, the sensitivity was 45.8% and the specificity was 85%. PLR was also significantly different between groups III and group IV. PLR was higher in Herring A and B classifications than in Herring B/C and C classifications. PLR had certain diagnostic value in both the necrosis stage and fragmentation stage as a risk factor.
本研究旨在探讨血小板与淋巴细胞比值（PLR）与儿童佩特氏病外侧柱分类之间的关系，并为临床诊断提供一种替代指标。此外，还探讨了 PLR 与儿童佩特氏病坏死分期的相关性。这是一项回顾性研究。我们收集了 2012 年至 2021 年我院收治的 74 例佩特氏病患儿和 60 例无股骨头坏死的健康对照组儿童的一般资料和临床参数。从医院信息系统中收集改良的赫林外侧柱分类，并对碎裂期病例组进行分组，计算 PLR、中性粒细胞与淋巴细胞比值（NLR）、淋巴细胞与单核细胞比值（LMR）和血小板与中性粒细胞比值（PNR）。将病例分为四组，赫林 A 和 B 为 I 组，赫林 B/C 和 C 为 II 组，健康对照组为 III 组，坏死组为 IV 组。统计分析不同分期儿童的血液学指标（NLR、PLR、LMR、PNR）。I 组 36 例，平均年龄 7.4±2.0 岁（3-11 岁）。II 组 23 例，平均年龄 7.4±1.9 岁（4-12 岁）。III 组 60 例，平均年龄 7.4±2.7 岁（4-13 岁）。IV 组 15 例，平均年龄 6.4±1.7 岁（3-10 岁）。I、II、III 和 IV 组的 PLR 平均值分别为 131.98±47.44、122.19±37.88、102.46±30.68 和 128.90±28.11。值得注意的是，I、II 和 III 组之间有统计学差异（P=0.003）。PLR 的最佳阈值为 130.25，灵敏度为 45.8%，特异性为 85%。III 组和 IV 组之间的 PLR 也有显著差异。赫林 A 和 B 分类的 PLR 高于赫林 B/C 和 C 分类。PLR 对坏死期和碎裂期均有一定的诊断价值，是一个危险因素。
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