电刺激对海马脑片制备物活力的影响。

Effect of electrical stimulation on the viability of the hippocampal slice preparation.

作者信息

Schurr A, Reid K H, Tseng M T, Edmonds H L, West C A, Rigor B M

出版信息

Brain Res Bull. 1986 Feb;16(2):299-301. doi: 10.1016/0361-9230(86)90045-6.

Abstract

Continuous electrical stimulation of rat hippocampal slices at a frequency of 1 Hz brought about a 50% decline in the evoked population spike amplitude at a rate 5 times faster than that caused by very low frequency (1/600 Hz) stimulation. Within 2 hr after the high frequency stimulation began the evoked response totally disappeared. By contrast low frequency stimulated slices maintained an evoked response for at least 9 hr. Continuous electrical stimulation, especially at high frequency seems to facilitate the deterioration of the in vitro hippocampal slice preparation.

摘要

以1赫兹的频率对大鼠海马切片进行连续电刺激，会使诱发群体峰电位幅度下降50%，其下降速度比极低频（1/600赫兹）刺激引起的快5倍。在高频刺激开始后的2小时内，诱发反应完全消失。相比之下，低频刺激的切片至少9小时内保持诱发反应。连续电刺激，尤其是高频刺激，似乎会加速体外海马切片标本的退变。