Anwyl R, Rowan M J
Br J Pharmacol. 1985 Sep;86(1):201-8. doi: 10.1111/j.1476-5381.1985.tb09450.x.
The effect of the tricyclic antidepressants imipramine and desipramine were studied on field potentials in the rat hippocampal slice. The electrically evoked stratum radiatum nerve volley, excitatory postsynaptic potential (e.p.s.p.) and pyramidal cell layer population spike (PS) were recorded in the CA1 region. At concentrations of 10(-6)M to 10(-5)M, impramine did not affect the amplitude of the nerve volley, e.p.s.p. or PS at low frequencies of stimulation (0.01 Hz). At higher frequencies of stimulation (1-100 Hz), imipramine caused a frequency-dependent block of the nerve volley, e.p.s.p. and PS. The time course of onset of the frequency-dependent block in the presence of imipramine was very slow. Maximum inhibition was reached after 3-4 h treatment with imipramine. Desipramine (10(-6)-10(-5)M) also caused a frequency-dependent block of the hippocampal field potentials. Only slight frequency-dependent block was observed in slices from rats injected in vivo with desipramine (10 mg kg-1) for 14 days.
研究了三环类抗抑郁药丙咪嗪和地昔帕明对大鼠海马切片场电位的影响。在CA1区记录电诱发的辐射层神经峰电位、兴奋性突触后电位（e.p.s.p.）和锥体细胞层群体峰电位（PS）。在10（-6）M至10（-5）M浓度下，低频刺激（0.01Hz）时，丙咪嗪不影响神经峰电位、e.p.s.p.或PS的幅度。在较高频率刺激（1-100Hz）时，丙咪嗪引起神经峰电位、e.p.s.p.和PS的频率依赖性阻滞。丙咪嗪存在时频率依赖性阻滞的起效时间过程非常缓慢。丙咪嗪处理3-4小时后达到最大抑制。地昔帕明（10（-6）-10（-5）M）也引起海马场电位的频率依赖性阻滞。在体内注射地昔帕明（10mg kg-1）14天的大鼠切片中仅观察到轻微的频率依赖性阻滞。
