Kaliszan R, Osmialowski K, Kobylczyk K
Chemotherapy. 1979;25(1):5-8. doi: 10.1159/000237815.
A significnat correlation has been found between the in vitro activity of 16 commonly employed sulphonamides and their molar refractivity. The molar refractivity has been shown to be a superior parameter for the description of the activity of sulphonamides than the sum of electronegativities of atoms making up a heterocyclic substituent in the sulphonamide molecule and molecular weight of the substituent.
已发现16种常用磺胺类药物的体外活性与其摩尔折射度之间存在显著相关性。结果表明，对于描述磺胺类药物的活性而言，摩尔折射度是一个比构成磺胺类药物分子中杂环取代基的原子电负性总和及取代基分子量更优越的参数。
