自噬在女性生殖系统中的作用：供该领域初学者至专家参考

Nakashima Akitoshi, Furuta Atsushi, Yamada Kiyotaka, Yoshida-Kawaguchi Mihoko, Yamaki-Ushijima Akemi, Yasuda Ippei, Ito Masami, Yamashita Satoshi, Tsuda Sayaka, Yoneda Satoshi, Cheng Shibin, Sharma Surendra, Shima Tomoko

Department of Obstetrics and Gynecology, Toyama Autophagy Team in Gynecology and Obstetrics, University of Toyama, Toyama 930-0194, Japan.

Departments of Pediatrics, Women and Infants Hospital of Rhode Island, Warren Alpert Medical School of Brown University, Providence, RI 02905, USA.

Biology (Basel). 2023 Feb 26;12(3):373. doi: 10.3390/biology12030373.

Autophagy is a fundamental process involved in regulating cellular homeostasis. Autophagy has been classically discovered as a cellular process that degrades cytoplasmic components non-selectively to produce energy. Over the past few decades, this process has been shown to work in energy production, as well as in the reduction of excessive proteins, damaged organelles, and membrane trafficking. It contributes to many human diseases, such as neurodegenerative diseases, carcinogenesis, diabetes mellitus, development, longevity, and reproduction. In this review, we provide important information for interpreting results related to autophagic experiments and present the role of autophagy in this field.

自噬是一种参与调节细胞内稳态的基本过程。自噬最初被发现是一种细胞过程，它非选择性地降解细胞质成分以产生能量。在过去几十年中，这一过程已被证明在能量产生、减少过量蛋白质、受损细胞器及膜运输等方面发挥作用。它与许多人类疾病相关，如神经退行性疾病、癌症发生、糖尿病、发育、长寿及生殖等。在本综述中，我们提供了重要信息以解读与自噬实验相关的结果，并阐述自噬在该领域中的作用。