p53 在人类健康与疾病中的功能与失能。
p53 Function and Dysfunction in Human Health and Diseases.
机构信息
Unit of Cellular Networks, Department of Research, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Department of Neurosciences, Images and Clinical Sciences, University G. D'Annunzio, 00131 Chieti, Italy.
出版信息
Biomolecules. 2023 Mar 9;13(3):506. doi: 10.3390/biom13030506.
Abstract
The p53 protein is a sequence-specific DNA-binding transcription factor that, in response to stressful stimuli, regulates gene expression related to multiple cellular functions including, but not limited to, cell cycle arrest, cell apoptosis, cell growth, DNA repair, cell metabolism, and the immune response [...].
摘要
p53 蛋白是一种序列特异性的 DNA 结合转录因子，它可以响应应激刺激，调节与多种细胞功能相关的基因表达，包括但不限于细胞周期停滞、细胞凋亡、细胞生长、DNA 修复、细胞代谢和免疫反应等。
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