Sheikh-Ahmad Mohammad, Saiegh Leonard, Shalata Anan, Bejar Jacob, Kreizman-Shefer Hila, Sirhan Majd F, Matter Ibrahim, Swaid Forat, Laniado Monica, Mubariki Nama, Rainis Tova, Rosenblatt Ilana, Yovanovich Ekaterina, Agbarya Abed
Institute of Endocrinology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, Israel.
The Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel.
Biomedicines. 2023 Mar 9;11(3):828. doi: 10.3390/biomedicines11030828.
Type I gastric neuroendocrine neoplasms (gNENs) are associated with atrophic gastritis and have a high recurrence rate, which means frequent endoscopies are required. The objective of this study was to identify factors predicting the local recurrence of type I gNENs. The clinical course and the pathological and biochemical data of patients with type I gNENs treated at Bnai Zion Medical Center between 2006 and 2022 were analyzed retrospectively. Twenty-seven type I gNENs were evaluated. The follow-up period was 41 months (range: 11-288 months). Recurrence of the tumor occurred in 13/27 (48%) patients after 35 months (median (M), interquartile range (IQR): 21-67.5). Serum gastrin levels were significantly higher in patients with recurrent disease versus patients with non-recurrent disease (788 vs. 394 ng/L; = 0.047), while the Ki-67 index was significantly lower in patients with recurrent disease versus patients with non-recurrent disease (1% vs. 3.5%; = 0.035). Tumor size, mitotic count, and serum chromogranin A levels did not correlate with recurrence. The present study emphasizes the role of gastrin in the pathogenesis of gNEN recurrence and highlights the debate regarding the ability of the Ki-67 index to predict the clinical course of this disease.
I型胃神经内分泌肿瘤（gNENs）与萎缩性胃炎相关，且复发率高，这意味着需要频繁进行内镜检查。本研究的目的是确定预测I型gNENs局部复发的因素。回顾性分析了2006年至2022年在贝纳伊锡安医疗中心接受治疗的I型gNENs患者的临床病程以及病理和生化数据。对27例I型gNENs进行了评估。随访期为41个月（范围：11 - 288个月）。13/27（48%）例患者在35个月后（中位数（M），四分位间距（IQR）：21 - 67.5）出现肿瘤复发。复发患者的血清胃泌素水平显著高于未复发患者（788 vs. 394 ng/L；P = 0.047），而复发患者的Ki-67指数显著低于未复发患者（1% vs. 3.5%；P = 0.035）。肿瘤大小、有丝分裂计数和血清嗜铬粒蛋白A水平与复发无关。本研究强调了胃泌素在gNEN复发发病机制中的作用，并突出了关于Ki-67指数预测该疾病临床病程能力的争议。
