Calcaterra Valeria, Magenes Vittoria Carlotta, Destro Francesca, Baldassarre Paola, Silvestro Giustino Simone, Tricella Chiara, Visioli Alessandro, Verduci Elvira, Pelizzo Gloria, Zuccotti Gianvincenzo
Pediatrics and Adolescentology Unit, Department of Internal Medicine, University of Pavia, 27100 Pavia, Italy.
Pediatric Department, "Vittore Buzzi" Children's Hospital, 20154 Milan, Italy.
Children (Basel). 2023 Mar 16;10(3):564. doi: 10.3390/children10030564.
Severe obesity remains one of the most important symptoms of Prader-Willi Syndrome (PWS), and controlling weight represents a crucial point in the therapeutical approach to the syndrome. We present an overview of different progressive patterns of growth that involve controlling weight in PWS. Mechanisms involved in the development of obesity and in preventive and therapeutic strategies to control weight gain are discussed. Early diagnosis, a controlled diet regimen, regular physical activity, follow-up by multidisciplinary teams, and hormonal treatment improved the management of excessive weight gain. In selected cases, a surgical approach can be also considered. Controlling weight in PWS remains a challenge for pediatricians. The importance of consulting different healthcare specialists, starting from the neonatal and pediatric age, is also considered as a crucial approach to controlling weight, as well as to limiting and preventing the onset of obesity and its complications.
重度肥胖仍然是普拉德-威利综合征（PWS）最重要的症状之一，控制体重是该综合征治疗方法中的关键环节。我们概述了涉及PWS体重控制的不同渐进性生长模式。讨论了肥胖发生机制以及控制体重增加的预防和治疗策略。早期诊断、控制饮食方案、规律体育活动、多学科团队随访以及激素治疗改善了对体重过度增加的管理。在特定病例中，也可考虑手术方法。对儿科医生而言，控制PWS患者的体重仍然是一项挑战。从新生儿期和儿童期开始就咨询不同医疗保健专家，这对于控制体重以及限制和预防肥胖及其并发症的发生也被视为一种关键方法。
