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药物摄入作为母乳喂养未启动和停止的一个因素:COVID-19大流行期间在希腊进行的一项前瞻性队列研究。

Medication Intake as a Factor for Non-Initiation and Cessation of Breastfeeding: A Prospective Cohort Study in Greece during the COVID-19 Pandemic.

作者信息

Tigka Maria, Metallinou Dimitra, Nanou Christina, Iliodromiti Zoi, Gryparis Alexandros, Lykeridou Katerina

机构信息

Department of Midwifery, University of West Attica, 12243 Athens, Greece.

Department of Obstetric Emergency, General and Maternity Hospital "Helena Venizelou", 11521 Athens, Greece.

出版信息

Children (Basel). 2023 Mar 18;10(3):586. doi: 10.3390/children10030586.

DOI:10.3390/children10030586
PMID:36980144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10047701/
Abstract

Pharmacological treatment may become a barrier for a mother's breastfeeding goals. We aimed to investigate maternal medication intake as a factor for non-initiation and cessation of breastfeeding and the effect of professional counseling on maternal decision-making. Throughout 2020, 847 women were recruited from five healthcare institutions. Information was gathered prospectively with an organized questionnaire through interview during hospitalization and through telephone at 1, 3 and 6 months postpartum. Results revealed that from the 57 cases of breastfeeding cessation due to medication intake, only 10.5% received evidence-based counseling from a physician. Unfortunately, 68.4% ( = 39/57) of the participants ceased breastfeeding due to erroneous professional advice. The compatibility of medicines with breastfeeding was examined according to the Lactmed and Hale classification systems, which showed discrepancy in 8 out of 114 medicines used, while 17.5% and 13.2% of the medicines, respectively, were not classified. Educational level, employment at six months postpartum, mode of delivery, previous breastfeeding experience, medication intake for chronic diseases, physician's recommendation and smoking before pregnancy were factors significantly correlated with breastfeeding discontinuation due to medication intake. The COVID-19 restrictions protected women from ceasing breastfeeding due to medication intake. Maternal and lactation consultancy should be strictly related to evidence-based approaches.

摘要

药物治疗可能会成为母亲实现母乳喂养目标的障碍。我们旨在调查母亲的药物摄入情况,将其作为母乳喂养未开始及停止的一个因素,并研究专业咨询对母亲决策的影响。在2020年全年,我们从五家医疗机构招募了847名女性。通过在住院期间进行访谈以及在产后1个月、3个月和6个月通过电话,使用一份有组织的问卷前瞻性地收集信息。结果显示,在因药物摄入而停止母乳喂养的57例病例中,只有10.5%的人接受了医生基于证据的咨询。不幸的是,68.4%(=39/57)的参与者因错误的专业建议而停止母乳喂养。根据Lactmed和Hale分类系统对药物与母乳喂养的兼容性进行了检查,结果显示在使用的114种药物中有8种存在差异,同时分别有17.5%和13.2%的药物未被分类。教育水平、产后6个月的就业情况、分娩方式、以前的母乳喂养经历、慢性病的药物摄入、医生的建议以及孕前吸烟是与因药物摄入而停止母乳喂养显著相关的因素。COVID-19限制措施使女性免于因药物摄入而停止母乳喂养。母婴和哺乳咨询应严格基于循证方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ca/10047701/e023b52f7cb3/children-10-00586-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ca/10047701/e023b52f7cb3/children-10-00586-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d6ca/10047701/e023b52f7cb3/children-10-00586-g001.jpg

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2
Evaluating strength of recommendations for commonly administered medications in lactating women.评估哺乳期妇女常用药物推荐的力度。
J Matern Fetal Neonatal Med. 2023 Dec;36(1):2163626. doi: 10.1080/14767058.2022.2163626.
3
The value of midwifery counseling during lactation as a key factor of pharmacovigilance.
哺乳期助产咨询作为药物警戒关键因素的价值。
Eur J Midwifery. 2022 Nov 24;6:65. doi: 10.18332/ejm/156439. eCollection 2022.
4
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Self-Reported Medication Use among Pregnant and Breastfeeding Women during the COVID-19 Pandemic: A Cross-Sectional Study in Five European Countries.COVID-19 大流行期间孕妇和哺乳期妇女自我报告的用药情况:五个欧洲国家的横断面研究。
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