Carmon David, Rohana Hanan, Azrad Maya, Peretz Avi
Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.
The Clinical Microbiology Laboratory, Tzafon Medical Center, Poriya, Tiberias 1528001, Israel.
Diagnostics (Basel). 2023 Mar 14;13(6):1094. doi: 10.3390/diagnostics13061094.
The gold standard diagnostic method for gastrointestinal infections is stool culture, which has limited sensitivity and long turnaround time. Infection diagnosis recently shifted to syndrome-based panel assays. This study employed the FilmArray Gastrointestinal Panel, which detects 22 pathogens simultaneously, to investigate gastrointestinal infection and pathogen distribution in 91 stool samples of patients hospitalized at the Tzafon Medical Center, Israel, during 2020, and to compare the clinical and demographic data of negative vs. positive samples. Among the 61 positive samples (67%), the most common pathogen was (34.4%). Positive test results were associated with a slightly younger patient age ( = 0.012), significantly higher post-diagnosis use of antibiotics (63.9% vs. 36.7%; = 0.014), and shorter length of stay and time to discharge ( = 0.035, = 0.003, respectively) than negative test results. To conclude, the FilmArray Gastrointestinal Panel enabled the early identification of causative infectious agents and enhanced clinical management and outcomes.
胃肠道感染的金标准诊断方法是粪便培养，但其敏感性有限且周转时间长。感染诊断最近转向了基于综合征的检测方法。本研究采用FilmArray胃肠道检测板，该检测板可同时检测22种病原体，以调查2020年期间在以色列北医疗中心住院的91例患者粪便样本中的胃肠道感染情况和病原体分布，并比较阴性和阳性样本的临床及人口统计学数据。在61份阳性样本（67%）中，最常见的病原体是（34.4%）。阳性检测结果与患者年龄稍小（P = 0.012）、诊断后使用抗生素的比例显著更高（63.9%对36.7%；P = 0.014）以及住院时间和出院时间更短（分别为P = 0.035、P = 0.003）有关，而阴性检测结果则不然。总之，FilmArray胃肠道检测板能够早期识别致病感染因子，并改善临床管理和治疗结果。
