Jost S P, Potten C S
Cell Tissue Kinet. 1986 Mar;19(2):155-60. doi: 10.1111/j.1365-2184.1986.tb00725.x.
Developing murine urothelium undergoes pronounced proliferation until at least 10 days after birth. Thereafter, both mitotic and [3H]TdR-labelling indices fall sharply with age. The ratio of labelling to mitotic indices also alters dramatically during development, which is probably due to both endoreduplication and changes in the relative durations of the DNA synthesis and mitotic phases. This ratio reaches stability at 5 weeks of age. The adult labelling and mitotic indices were 0.11 and 0.019% respectively, indicating a very slow turnover.
发育中的小鼠尿路上皮在出生后至少10天内经历显著的增殖。此后，有丝分裂指数和[3H]TdR标记指数均随年龄急剧下降。在发育过程中，标记指数与有丝分裂指数的比值也发生显著变化，这可能是由于核内复制以及DNA合成期和有丝分裂期相对持续时间的改变所致。该比值在5周龄时达到稳定。成年小鼠的标记指数和有丝分裂指数分别为0.11%和0.019%，表明细胞更新非常缓慢。
